N-[5-(胺基磺醯基)-4-甲基-1,3-噻唑-2-基]-N-甲基-2-[4-(2-吡啶基)-苯基]-乙醯胺之游離鹼的順丁烯二酸鹽,醫藥調配物、製造方法及其用途农业专利-农业学术服务平台

发明人:: BACHHAV, YOGESHWAR,贝琪海薇　姚杰西华,貝琪海薇　姚傑西華,SCHWAB, WILFRIED,史其华柏　威尔佛瑞德,史其華柏　威爾佛瑞德,BIRKMANN, ALEXANDER,比尔克曼　爱立克瑟登,比爾克曼　愛立克瑟登,BONSMANN, SUSANNE,邦斯曼　苏珊,邦斯曼　蘇珊,GOLDNER, THOMAS,高登尼尔　汤马士,高登尼爾　湯馬士,贝琪海薇姚杰西华,貝琪海薇姚傑西華,史其华柏威尔佛瑞德,史其華柏威爾佛瑞德,比尔克曼爱立克瑟登,比爾克曼愛立克瑟登,邦斯曼苏珊,邦斯曼蘇珊,高登尼尔汤马士,高登尼爾湯馬士

摘要：: The present invention relates to the field of anti-viral active agents, particularly to salts, more particularly to a maleate salt of the free base of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)-phenyl]-acetamide, to pharmaceutical formulations thereof as well as to methods for the production of these salts. The present invention also relates to the use of theses salts and of respective pharmaceutical formulations thereof in methods of treatment and/or prevention of human herpes simplex virus infections, particulary infections caused by HSV-1 and HSV-2.本發明係關於抗病毒活性劑領域、特定地N-[5-(胺基磺醯基)-4-甲基-1,3-噻唑-2-基]-N-甲基-2-[4-(2-吡啶基)-苯基]-乙醯胺之游離鹼之鹽、更特定地順丁烯二酸鹽、其醫藥調配物以及產生該等鹽之方法。本發明亦係關於該等鹽及其各別醫藥調配物在治療及/或預防人類單純疱疹病毒感染、尤其由HSV-1及HSV-2引起之感染之方法中之用途。