The present invention relates to an improved and shortened synthesis of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acet-amide and the mesylate monohydrate salt thereof by using boronic acid derivatives or borolane reagents while avoiding toxic organic tin compounds and to the mesylate monohydrate salt of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acet-amide which has demonstrated increased long term stability and release kinetics from pharmaceutical compositions.本發明關於N-[5-(胺磺醯基)-4-甲基-1,3-噻唑-2-基]-N-甲基-2-[4-(2-吡啶基)苯基]乙醯胺以及其甲磺酸鹽單水化物鹽之經改良且縮短耗時之合成方法，所述合成方法是使用硼酸衍生物或硼雜環戊烷試劑進行，同時可避免有毒的有機錫化合物，且關於N-[5-(胺磺醯基)-4-甲基-1,3-噻唑-2-基]-N-甲基-2-[4-(2-吡啶基)苯基]乙醯胺之甲磺酸鹽單水化物鹽，所述鹽顯示增加之長期穩定性以及自醫藥組成物中之釋放動力學。
