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3-AMINOBENZAMIDE COMPOUNDS AND VANILLOID RECEPTOR SUBTYPE 1 (VR1) INHIBITORS
专利权人:
Yoshihisa Koga;Masahiro Sakata;Takashi Watanabe;Wataru Kondo;Shinji Yata;Takuya Matsuo
发明人:
Yoshihisa Koga,Shinji Yata,Takashi Watanabe,Takuya Matsuo,Masahiro Sakata,Wataru Kondo
申请号:
US13155143
公开号:
US20120115827A1
申请日:
2011.06.07
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention relates to a novel 3-aminobenzamide, compound represented by the following formula which effectively inhibits vanilloid receptor subtype 1 (VR1) activity (wherein, for example, R1 is a C1-6 alkyl group which may be substituted, R2 is a hydrogen atom, a C1-6 alkyl group or a C1-6 alkoxy group which may be substituted, R3 is a hydrogen atom or a C1-6 alkyl group, R4 is a C1-6 alkyl group, a C1-6 alkoxy group, or a halo C1-6 alkyl group, m is an integer of 1 to 5 and P is a carbon or hetero ring) or a pharmaceutically acceptable salt thereof. The pharmaceutical composition comprising as active ingredients the 3-aminobenzamide, compound or a pharmaceutically acceptable salt thereof is useful for treating diseases involved in VR1 activity such as pain, acute pain, chronic pain, neuropathicpain, rheumatoid arthritis pain, and neuralgia.
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