PHARMACEUTICAL COMPOSITION COMPRISING THE EXTRACTION OF LEAF OF NELUMBO NUCIFERA AS AN EFFECTIVE COMPONENT FOR PREVENTION OR TREATMENT OF THROMBOSIS AND HEALTH FUNCTIONAL FOOD COMPRISING THE SAME
재단법인 경북바이오산업연구원;안동대학교 산학협력단;재단법인 경북바이오산업연구원;안동대학교 산학협력단;GYEONGBUK INSTITUTE FOR BIO INDUSTRY;ANDONG NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
SOHN HO YONG,손호용,PARK JONG YI,박종이
申请号：
KR1020200001189
公开号：
KR1020200006137A
申请日:
2020.01.06
申请国别(地区):
KR
年份:
2020
代理人:
摘要：
The present invention relates to a pharmaceutical composition for preventing or treating thrombosis containing lotus leaf (leaf of Nelumbo nucifera) extract as an active ingredient, and health functional food and, more specifically, to a pharmaceutical composition for preventing or treating/alleviating thrombosis through potent platelet aggregation inhibition and blood coagulation inhibition by using the hot water extract of lotus leaves or ethanol extract, a hexene fraction thereof, an ethyl acetate fraction, and a butanol fraction as active ingredients； and health functional food. The lotus leaf extract as an active ingredient of the pharmaceutical composition for preventing or treating thrombosis and the health functional food by the present invention is expected to be used for the prevention and treatment of thrombosis such as ischemic stroke and hemorrhagic stroke through the improvement of blood circulation by showing no hemolytic activity against human erythrocytes, having excellent thermal stability, showing no loss in a blood coagulation factor inhibitory effect and a thrombus generation-related enzyme inhibitory effect even in acidic conditions and plasma of pH 2 while inhibiting thrombus generation-related enzymes and blood coagulation factors and exhibiting a potent antithrombotic activity by an aggregation inhibitory effect of platelets performing the initiating role of thrombus formation. The active ingredients are a very useful invention for pharmaceutical industries and food industries by having an excellent effect of being processed into various forms such as extract, powder, pills, tablets, etc. and being prepared in a form which can be taken at all times.본 발명은 연잎(Leaf of Nelumbo nucifera) 추출물을 유효성분으로 함유하는 혈전증(thrombosis)의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품에 관한 것으로서, 보다 구체적으로는, 연잎의 열수 추출물 또는 에탄올 추출물 및 이들의 헥센 분획물, 에틸아세테이트 분획물 및 부탄올 분획물을 유효성분으로 하는 강력한 혈소판 응집 저해 및 혈액 응고 저해를 통한 혈전증의 예방 또는 치료/개선용 약학적 조성물 및 건강 기능 식품에 관한 것이다. 본 발명의 혈전증의 예방 또는 치료용 약학적 조성물 및 건강 기
