PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF THROMBOSIS COMPRISING THE EXTRACTION OF LETTUCE AS AN EFFECTIVE COMPONENT AND HEALTH FUNCTIONAL FOOD COMPRISING THE SAME
ANDONG NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
SOHN, HO YONG,손호용,SUNG, HWA JUNG,성화정
申请号：
KR1020170064842
公开号：
KR1019163400000B1
申请日:
2017.05.25
申请国别(地区):
KR
年份:
2018
代理人:
摘要：
The present invention relates to a pharmaceutical composition and a health functional food product containing a Lactica sativa L. extract as an effective component for preventing or treating thrombosis. More specifically, the pharmaceutical composition contains an ethyl acetate fraction, which is obtained by fractionating an ethanol extract of Lactica sativa L. sequentially with organic solvents of hexane, ethyl acetate, and butanol, a water residue after the fractionation, or a mixture thereof as an effective component, and thus, the composition is capable of preventing or treating thrombosis by inhibiting blood coagulation and inhibiting platelet agglutination. The Lactica sativa L. extract, which is an effective component of the pharmaceutical composition and the health functional food product of the present invention, indicates a strong antithrombotic activity, which has effects of inhibiting thrombus generation-related enzymes and blood coagulation factors as well as inhibiting the agglutination of platelets functioning as a thrombus generation initiator, while not having a hemoclastic activity to human red blood cells at all, having excellent thermal stability, and preventing the effects of inhibiting the blood coagulation factors and thrombus generation-related enzymes from being lost even in a pH 2 acidic condition and blood plasma, and accordingly, the extract is expected to be used for preventing and treating thrombosis such as ischemic stroke and hemorrhagic stroke. Also, since the effective component is able to be processed into liquid, powder, pills, tablets, and the like to be taken anytime, the present invention is able to be very beneficial for pharmaceutical and food industries.본 발명은 상추(Lactica sativa L.) 추출물을 유효성분으로 함유하는 혈전증(thrombosis)의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품에 관한 것으로서, 보다 구체적으로는, 상추의 에탄올 추출물을 헥센, 에틸아세테이트 및 부탄올의 유기 용매로 순차 분획하여 수득되는 에틸아세테이트 분획물, 분획 후의 물 잔류물 또는 이의 혼합물을 유효성분으로 하여 혈액 응고 저해 및 혈소판 응집 저해를 통한 혈전증의 예방 또는 치료/개선용 약학적 조성물 및 건강 기능 식품에 관한
