PHARMACEUTICAL COMPOSITION COMPRISING THE EXTRACT OF ANGELICA ACUTILOBA AS AN EFFECTIVE COMPONENT FOR PREVENTION OR TREATMENT OF THROMBOSIS AND HEALTH FUNCTIONAL FOOD COMPRISING THE SAME
The present invention a pharmaceutical composition and a health functional food for preventing or treating thrombosis, comprising an extract of Angelica acutiloba as an active ingredient, and more particularly, to a pharmaceutical composition for preventing or treating thrombosis, comprising an ethanol extract of Angelica acutiloba as an active ingredient, and a health functional food comprising the extract. The extract of Angelica acutiloba as an active ingredient of the pharmaceutical composition and the health functional food for preventing or treating thrombosis according to the present invention, as proved through examples of the present specification, is produced by extracting a root portion of Angelica acutiloba with ethanol or the like to prepare an extract, followed by fractionation with hexane and then sequential fractionation using ethyl acetate. Of these, the ethyl acetate fraction exhibiting antithrombotic activity through an excellent blood coagulation inhibiting effect can efficiently inhibit thrombus generation, and can be used for preventing and treating thrombosis such as ischemic stroke and hemorrhagic stroke through improvement of blood circulation. In particular, the extract of Angelica acutiloba according to the present invention has no acute oral toxicity, retains excellent thermal stability, and has no loss in blood coagulation inhibition and activation effects even in an acidic condition of pH 2 and in the plasma, so that the extract can be processed into various types of an extract, a powder, a pill, and a tablet and thus be taken at any time. Accordingly, the present invention is very useful for the pharmaceutical industry and the food industry.본 발명은 일당귀(Angelicaacutiloba) 추출물을 유효성분으로 함유하는 혈전증(thrombosis)의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품에 관한 것으로서, 보다 구체적으로는, 일당귀의 에탄올 추출물을 유효성분으로 함유하는 것을 특징으로 하는 혈전증의 예방 또는 치료용 약학적 조성물 및 상기 추출물을 포함하는 건강 기능 식품에 관한 것이다. 본 발명의 혈전증의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품의 유효성분으로서의 일당귀 추출물은, 본 명세서의 실시예를 통해 증명된 바와 같이, 일당귀 지하부를
