PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF THROMBOSIS COMPRISING THE ETHYLACETATE FRACTION OF SHIITAKE MUSHROOM EXTRACT AS AN EFFECTIVE COMPONENT AND HEALTH FUNCTIONAL FOOD COMPRISING THE SAME
재단법인 경북바이오산업연구원;GYEONGBUK INSTITUTE FOR BIO INDUSTRY;안동대학교 산학협력단;재단법인 경북바이오산업연구원;안동대학교 산학협력단;ANDONG NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
손호용,박종이,김종식,이만효,SOHN HO YONG,PARK JONG YI,KIM JONG SIK,LEE MAN HYO
申请号：
KR1020180049657
公开号：
KR1020190125632A
申请日:
2018.04.30
申请国别(地区):
KR
年份:
2019
代理人:
摘要：
The present invention relates to an antithrombotic composition containing ethyl acetate fraction of shiitake mushroom (Shiitake mushroom, Lentinus edodes ) extract as an active ingredient, and more particularly, to an ethyl acetate fraction of hydrothermal extract of shiitake mushroom as an active ingredient. A pharmaceutical composition for the prevention or treatment / improvement of thrombosis through inhibition of blood coagulation and inhibition of platelet aggregation and a dietary supplement. Ethyl acetate fraction of shiitake mushroom extract as an active ingredient of the pharmaceutical composition for preventing or treating thrombosis and health functional food of the present invention, as demonstrated through the examples herein, clotting production-related enzyme inhibition and blood coagulation factor It exhibits strong antithrombotic activity and platelet aggregation inhibitory activity by inhibition of oxidative activity, shows no hemolytic activity against human erythrocytes, has excellent thermal stability, and is associated with blood clotting enzymes and blood coagulation under acidic conditions and plasma of pH 2. Since there is no loss of factor inhibitory effect and platelet aggregation inhibitory effect, it is expected to be used for the prevention and treatment of thrombosis such as ischemic stroke and hemorrhagic stroke by improving blood circulation, and the active ingredient is extract, powder, pill, tablet It can be processed into various forms such as It is a very useful invention for the pharmaceutical industry and the food industry because it has an excellent effect.본 발명은 표고버섯(Shiitake mushroom, Lentinus edodes) 추출물의 에틸아세테이트 분획물을 유효성분으로 함유하는 항혈전 조성물에 관한 것으로서, 보다 상세하게는, 표고버섯의 열수 추출물의 에틸아세테이트 분획물을 유효성분으로 함유하는 혈액 응고 저해 및 혈소판 응집 저해를 통한 혈전증의 예방 또는 치료/개선용 약학적 조성물 및 건강 기능 식품에 관한 것이다. 본 발명의 혈전증의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품의 유효성분으로서의 표고버섯 추출물의 에틸아세테이트 분획물은, 본 명세서의 실시예를 통해 증명된 바와 같이, 혈전 생성 관련 효소 저해 및 혈액 응고 인자의 저해에 의한 강력한 항혈전 활성과 혈소판 응집 저해 활성을 나
