PHARMACEUTICAL COMPOSITION COMPRISING THE EXTRACT OF ACORN POLLEN AS AN EFFECTIVE COMPONENT FOR PREVENTION OR TREATMENT OF THROMBOSIS AND HEALTH FUNCTIONAL FOOD COMPRISING THE SAME
안동대학교 산학협력단;ANDONG NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
손호용,정철의,SOHN HO YONG,JUNG CHULEUI
申请号：
KR1020180157585
公开号：
KR1020200069965A
申请日:
2018.12.07
申请国别(地区):
KR
年份:
2020
代理人:
摘要：
The present invention relates to a pharmaceutical composition and a health functional food for preventing or treating thrombosis containing an acorn pollen (Pollen of Quercus sp.) extract as an active ingredient, and more specifically, an acorn pollen ethanol extract, its It relates to a pharmaceutical composition for preventing or treating/improving thrombosis through inhibiting blood clotting and inhibiting platelet aggregation by using ethyl acetate fraction, butanol fraction, water residue after organic solvent fraction, or a mixture thereof as an active ingredient and a health functional food. . The pharmaceutical composition for preventing or treating thrombosis of the present invention and the acorn pollen extract as an active ingredient in a dietary supplement are effective in inhibiting the aggregation of platelets that serve to initiate thrombus generation together with inhibition of thrombus-related enzymes and blood clotting factors. In addition, it exhibits strong antithrombotic activity, and does not show any hemolytic activity against human red blood cells, has excellent thermal stability, and has an effect of inhibiting blood clotting factor inhibition and blood clot production-related enzyme inhibitory effects in acidic conditions and plasma at pH 2. Since it does not appear, it is expected to be used for the prevention and treatment of thrombosis such as ischemic stroke and hemorrhagic stroke through improvement of blood circulation, and the active ingredient is processed into various forms such as extract, powder, pills, tablets and can be taken at all times. It is a very useful invention in the pharmaceutical industry and the food industry because it has excellent effects that can be formulated in the form.본 발명은 도토리 화분(Pollen of Quercus sp.) 추출물을 유효성분으로 함유하는 혈전증(thrombosis)의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품에 관한 것으로서, 보다 구체적으로는, 도토리 화분 에탄올 추출물, 이의 에틸아세테이트 분획물, 부탄올 분획물, 유기용매 분획 후의 물 잔류물 또는 이들의 혼합물을 유효성분으로 하는 혈액 응고 저해 및 혈소판 응집 저해를 통한 혈전증의 예방 또는 치료/개선용 약
