PHARMACEUTICAL COMPOSITION COMPRISING THE EXTRACTION OF NODULUS OF NELUMBINUS RHIZOMA AS AN EFFECTIVE COMPONENT FOR PREVENTION OR TREATMENT OF THROMBOSIS AND HEALTH FUNCTIONAL FOOD COMPRISING THE SAME
The present invention relates to the use of Nodulus of NelumbinisThe present invention relates to a pharmaceutical composition and a health functional food for preventing or treating thrombosis which comprises an extract of rheumatoid arthritis and rhizoma as an active ingredient and more specifically to a pharmaceutical composition and a health functional food for preventing or treating thrombosis comprising an extract of rheumatic ethanol and its butanol fraction or a water residue after sequential organic solvent fraction And a pharmaceutical composition for preventing or treating / improving thrombosis through inhibition of blood clotting and a health functional food. The pharmaceutical composition for the prevention or treatment of thrombosis according to the present invention and the rheumatoid extract as an active ingredient of the health functional food are effective for inhibiting thrombogenesis-related enzymes and blood coagulation factors and for inhibiting the aggregation of platelets, Exhibit strong antithrombotic activity, exhibit no hemolytic activity on human erythrocytes, exhibit excellent thermal stability, exhibit an acidic condition of pH 2 and a loss of blood coagulation factor inhibitory effect and thrombogenic enzyme-inhibiting effect even in plasma Therefore, it is expected that it can be used for prevention and treatment of thrombosis such as ischemic stroke and hemorrhagic stroke through improvement of blood circulation. The active ingredient can be processed into various forms such as extract, powder, The pharmaceutical industry and the pharmaceutical industry, Industrially very useful inventions.본 발명은 우절(Nodulus of Nelumbinisrhizoma) 추출물을 유효성분으로 함유하는 혈전증(thrombosis)의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품에 관한 것으로서, 보다 구체적으로는, 우절 에탄올 추출물 및 이의 부탄올 분획물 또는 순차적 유기 용매 분획 후의 물 잔류물을 유효성분으로 하는 강력한 혈소판 응집 저해 및 혈액 응고 저해를 통한 혈전증의 예방 또는 치료/개선용 약학적 조성물 및 건강 기능 식품에 관한 것이다. 본 발명의 혈전증의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품의 유효성분으로서의 우절 추출물은 혈전 생성 관련 효소 및 혈액 응고 인자의 저해와 함께 혈전
