CHEONG, CHAN SEONG,정찬성,KIM, DONG JIN,김동진,PARK, KI DUK,박기덕,KIM, YUN KYUNG,김윤경,PYO, JUNG IN,표정인,KIM, HYUN TAE,김현태,HWANG, ON YOU,황온유,ASHRAFUZZAMAN MD.,아쉬라,SONG, CHI MAN,송치만,KIM, YOUNG SOO,김영수
申请号：
KR1020120034483
公开号：
KR1020130112248A
申请日:
2012.04.03
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A composition containing a pyrazolopyrimidine derivative compound for suppressing NO generation and a pharmaceutical composition containing the pyrazolopyrimidine derivative compound for preventing and treating neurological disorders are provided to suppress NO generation in vivo and to treat neurological disorders caused by functional disturbance and apoptosis of neural cells.CONSTITUTION: A pyrazolopyrimidine derivative compound of chemical formulas I-VII or a pharmaceutically acceptable salt thereof is provided. A pharmaceutical composition for suppressing NO generation contains a pharmaceutically acceptable carrier or diluent and the compounds as active ingredients. A composition for treating neurological disorders contains the pharmaceutically acceptable carrier or diluent and the compounds as active ingredients. The neurological diseases are selected among Parkinsons disease, Alzheimers disease, Huntingtons disease, amylotrophic lateral sclerosis, epilepsia, depression, pain, anxiety, and neurodegenerative diseases.COPYRIGHT KIPO 2013본 발명은 피라졸로피리미딘 유도체 화합물을 포함하는 산화질소 생성 억제용 조성물 및 뇌신경 질환 예방 및 치료용 약학적 조성물에 관한 것으로서, 생체 내 산화질소의 생성을 억제할 수 있고, 산화질소의 과다생성에 따른 신경 세포의 기능장애 및 사멸로 인하여 야기되는 뇌신경 질환, 특히 파킨슨병, 알츠하이머 치매, 헌팅턴병, 루게릭병, 간질, 우울증, 불면증, 불안증 및 퇴행성 뇌신경 질환 등을 치료하는데 사용할 수 있다.
