AEBI, Johannes,AMREIN, Kurt,HORNSPERGER, Benoît,KUHN, Bernd,LIU, Yonfu,MAERKI, Hans P.,MARTIN, Rainer E.,MAYWEG, Alexander V.,MOHR, Peter,TAN, Xuefei
申请号：
ES13716291
公开号：
ES2655066T3
申请日:
2013.04.15
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
Compounds of formula (I) ** Formula ** in which R1, R2, R3 and R4 are independently selected from H, halogen, cyano, nitro, alkoxycarbonyl, cycloalkoxycarbonyl, substituted aminocarbonyl, substituted aminosulfonyl, alkyl, haloalkyl, cycloalkyl, alkoxy , haloalkoxy and cycloalkoxy, wherein the substituted aminocarbonyl and the substituted aminosulfonyl are substituted on the nitrogen atom with one to two substituents independently selected from H, alkyl, cycloalkyl, hydroxyalkyl and alkoxyalkyl； R5 is H, halogen, alkyl or cycloalkyl； R6 is H, alkyl, haloalkyl, cycloalkyl, substituted aryl or substituted heteroaryl, in which the substituted aryl or substituted heteroaryl are substituted with R19, R20 and R21； R7, R8, R9, R10, R11 and R12 are independently selected from H, halogen, alkyl and haloalkyl； A is - (CR13R14) p-NR15R16 or - (CR13R14) p-OR16； R13 and R14 are independently selected from H, alkyl, haloalkyl, cycloalkyl and halocycloalkyl； R15 is H, alkyl, haloalkyl, cycloalkyl, hydroxyalkyl, alkoxyalkyl or haloalkoxyalkyl； R16 is H, alkyl, haloalkyl, cycloalkyl, hydroxyalkyl, alkoxyalkyl, haloalkoxyalkyl, oxetanylalkyl, -CH2- C (O) OH, -CH2-C (O) OR17, -CH2-C (O) -NR17R18, -S (O ) R17, -S (O) 2R17, -S (O) 2OR17, -S (O) 2NR17R18, -C (O) R17, - C (O) OR17 or -C (O) NR17R18； R17 is alkyl, hydroxyalkyl, haloalkyl, cycloalkyl, alkylcycloalkyl, alkylcycloalkylalkyl, cycloalkylalkyl, cycloalkoxyalkyl, cycloalkylalkoxyalkyl, alkoxyalkyl, haloalkoxyalkyl, alkoxyalkoxyalkyl or substituted heteroaryl, where R22 is substituted, R22； R18 is H, alkyl, haloalkyl, cycloalkyl, alkoxyalkyl, haloalkoxyalkyl or hydroxyalkyl； R19, R20, R21, R22, R23 and R24 are independently selected from H, halogen, alkyl, haloalkyl, cycloalkyl, alkoxy and haloalkoxy； n is zero, 1 or 2； p is zero or 1； or pharmaceutically acceptable salts or esters； and wherein the term "alkyl" denotes a monovalent linear or branched saturated hydrocarbon group of 1 to 12 carbon atoms.Compuestos de fórmula (I)**Fór
