DEHMLOW, HENRIETTA,KUHN, BERND,OBST SANDER, ULRIKE,ROEVER, STEPHAN,SCHULZ-GASCH, TANJA,WRIGHT, MATTHEW
申请号：
ES08717926
公开号：
ES2375586T3
申请日:
2008.03.18
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
Compounds of the formula (I) in which X is N or CH； R1 is lower alkyl, fluor-lower alkyl, (lower alkoxy)-lower alkyl, cycloalkyl, cycloalkyl-lower alkyl, aryl, aryl-lower alkyl, heterocyclyl, heterocyclyl-lower alkyl, heteroaryl or heteroaryl-lower alkyl, wherein a cycloalkyl , aryl, heterocyclyl or heteroaryl may be optionally substituted by 1-5 substituents independently selected from the group consisting of halogen, lower alkyl, fluor-lower alkyl, lower alkoxy, (lower alkoxy)-lower alkyl and fluor-lower alkoxy； R2 is lower alkyl, (lower alkoxy)-lower alkyl, halogen-lower alkyl, lower alkenyl, cycloalkyl, cycloalkyl-lower alkyl, aryl, aryl-lower alkyl, heterocyclyl, heterocyclyl-lower alkyl, heteroaryl or heteroaryl-lower alkyl, in wherein a cycloalkyl, aryl, heterocyclyl or heteroaryl may be optionally substituted by 1 to 5 substituents independently selected from the group consisting of halogen, lower alkyl, fluor-lower alkyl, lower alkoxy and fluor-lower alkoxy； R3 is aryl or heteroaryl, whose aryl or heteroaryl may be optionally substituted by 1-5 substituents independently selected from the group consisting of halogen, CN, lower alkyl, fluor-lower alkyl, lower alkoxy and fluor-lower alkoxy； R4, R5, R6, R7, R8, R9, R10 and R11 independently of each other are hydrogen or lower alkyl, or R4 and R5 are linked together, or R6 and R7 are linked together, or R8 and R9 are linked together yes, or R10 and R11 are linked together, to form a ring together with the carbon atom to which they are attached, and -R4-R5-, -R6- R7-, -R8-R9- and / or -R10- R11- is - (CH2) 2-6-； and pharmaceutically acceptable salts thereof. Where lower means a group of one to seven carbon atom (s).Compuestos de la fórmula (I) en la que X es N o CH； R1 es alquilo inferior, fluor-alquilo inferior, (alcoxi inferior)-alquilo inferior, cicloalquilo, cicloalquil-alquilo inferior, arilo, aril-alquilo inferior, heterociclilo, heterociclil-alquilo inferior, heteroarilo o heteroaril-alquilo inferior, en
