VAN DER LOUW, JAAP,TEERHUIS, NEELTJE MIRANDA,LOMMERSE, JOHANNES PETRUS MARIA,STOCK, HERMAN, THIJS,HERMKENS, PEDRO HAROLD HAN
申请号：
CA2562571
公开号：
CA2562571C
申请日:
2005.04.21
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The compounds of the subject invention have a structure according to formulaI: wherein X is S or SO2； R1 is (1C-6C)alkyl, (3C-6C)alkenyl, or (3C-6C)alkynyl, each optionally subst ituted with (3C-6C)cycloalkyl, OH, OC(O)(1C-4C)alkyl, (1C- 4C)alkoxy, halogen, cyano, formyl, C(O)(1C-4C)alkyl, CO2H,CO2(1C- 4C)alkyl, C(O)NR5R6, S(O)(1C-4C)alkyl or S(O)2(1C-4C)alkyl； R2 ishydrogen, (1C-4C)alkyl or C(O)(1C-4C)alkyl； R3 is a phenyl group optionallysubstituted with (1C-4C)alkyl, (1C-4C)fluoroalkyl, (1C-4C)alkoxy, (1C-4C)fluoroalkoxy, halogen, cyano or nitro； or R3 is a 5- or 6-membered aromaticheterocyclic ring structure optionally substituted with (1C-4C)alkyl, (1C-4C)fluoroalkyl, (1C-4C)alkoxy, halogen or cyano； R4 is a phenyl group or anaromatic 6-membered heterocycle, substituted at the ortho position with 1-hydroxy(1C-4C)alkyl, (1C-4C)alkoxy, C(O)(1C- 4C)alkyl, CO2(1C-4C)alkyl,C(O)NH2, cyano, nitro, or CH=NOR7, and optionally further substituted with (1C-2C)alkyl, (1C-2C)fluoroalkyl or halogen； R5 is 2-pyridyl optionallysubstituted with (1C-2C)alkyl, (1C- 2C)fluoroalkyl or halogen； or R5 and R6are independently hydrogen or (1C-4C)alkyl； R7 is hydrogen or C(O)(1C-4C)alkyl； R8 , R9 , R10 are independently hydrogen, (1C-2C)alkyl, fluoro orchloro； or a salt or hydrate form thereof.
