HUGHES, PATRICK M,派崔克M 修吉,派崔克M 修吉,OLEJNIK, OREST,欧雷斯 欧尼克,歐雷斯 歐尼克,WHITCUP, SCOTT M,史考特M 怀可普,史考特M 懷可普,BURKE, JAMES A,詹姆士A 巴克,詹姆士A 巴克
申请号：
TW094101719
公开号：
TWI366471B
申请日:
2005.01.20
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
Compositions, and methods of using such compositions, useful for injection into the posterior segments of human or animal eyes are provided. Such compositions include small particles of a poorly soluble therapeutic agent that facilitates formation of concentrated regions of the therapeutic agent in the retinal pigmented epithelium of an eye. The particles are formed by combining a therapeutic agent with an ophthalmically acceptable polymer component. The particles have sizes less than about 3000 nanometers, and in some cases, less than about 200 nanometers. One example of a composition includes particles of triamcinolone acetonide and hyaluronic acid have a size less than about 3000 nanometers.本發明提供用於注射至人類或動物眼睛後段之組合物及使用該等組合物之方法。該等組合物包含難溶治療藥劑之微粒,該微粒有助於在眼睛視網膜色素上皮層中形成該藥劑之集中區域。該等微粒係藉由將一藥劑與一眼科可接受之聚合物組份組合而形成,該等微粒具有小於約3000奈米之粒徑,且在某些情況下小於約200奈米。一種組合物之實例包括粒徑小於約3000奈米之去炎松丙酮(triamcinolone acetonide)與玻尿酸(hyaluronic acid)之微粒。
