Burke, James A.,Olejnik, Orest,Hughes, Patrick M.,Whitcup, Scott M.
申请号：
AU2014250659
公开号：
AU2014250659A1
申请日:
2014.10.16
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
#$%^&*AU2014250659A120141106.pdf#####H:\mdt\Interwoven\NRPortbl\DCC\MIDT\6883277_.doc-16/10/2014 COMPOSITIONS FOR LOCALIZED THERAPY OF THE EYE, COMPRISING PREFERABLY TRIAMCINOLONE ACETONIDE AND HYALURONIC ACID Abstract 5 Compositions, and methods of using such compositions, useful for injection into the posterior segments of human or animal eyes are provided. Such compositions include small particles of a poorly soluble therapeutic agent that 10 facilitates formation of concentrated regions of the therapeutic agent in the retinal pigmented epithelium of an eye. The particles are formed by combining a therapeutic agent with an ophthalmically acceptable polymer component. The particles have sizes less than about 3000 nanometers, 15 and in some cases, less than about 200 nanometers. One example of a composition includes particles of triamcinolone acetonide and hyaluronic acid have a size less than about 3000 nanometers.
