VITE, GREGORY D.,LEAMON, CHRISTOPHER P.,VLAHOV, IONTCHO R.,KIM, SOONG-HOON
申请号：
CA2655668
公开号：
CA2655668C
申请日:
2007.05.25
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention is directed to aziridinyl epothilone compounds asfurther described herein, and/or pharmaceutically-acceptable salts and/orsolvatesthereof having the following Formula:(see above formula)wherein K is -O-, -S-, or -NR7-； A is -(CR8R9)-(CH2)m-Z- wherein Z is--(CHR10)-, -C(=O)-, -C(=O)-C(=O)-, -OC(=O)-, -N(R11)C(=O)-, -SO2-, or--N(R11)SO2-； B1 is hydroxyl or cyano and R1 is hydrogen or B1 and R1 aretakentogether to form a double bond； R2, R3, and R5 are, independently, hydrogen,alkyl,substituted alkyl, aryl or substituted aryl； or R2 and R3 may be takentogether withthe carbon to which they are attached to form an optionally substitutedcycloalkyl；R4 is hydrogen, alkyl, alkenyl, substituted alkyl, substituted alkenyl, aryl,orsubstituted aryl； R6 is hydrogen, alkyl or substituted alkyl； R7, R8, R9, R10,R11 andR12 are independently hydrogen, alkyl, substituted alkyl, cycloalkyl,substitutedcycloalkyl, aryl, substituted aryl, heterocycloalkyl, substitutedheterocycloalkyl,heteroaryl, or substituted heteroaryl； and R13 is aryl, substituted aryl,heteroaryl orsubstituted heteroaryl.
