A compound of formula (I) in which: Z is O； X and Y are independently selected from the group consisting of O, OCO, S, SO, SO2, CO, CO2, NR10, NR11CO, NR12CONR13, NR14CO2, NR15SO2, NR16SO2NR17, SO2NR18, CONR19, halogen, nitro and cyano, or X or And they are absent； R1 is hydrogen, CH3, OH, OCH3, SH, SCH3, OCOR21, SOR22, SO2R23, SO2NR24R25, CO2R26, CONR27R28, NH2 NR29SO2NR30R31, NR32SO2R33, NR34COR35, NR36CO2R37, NR38CONR39R40, halogen, nitro or nitro； R2 and R3 are independently hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heterocycle, substituted heterocycle, aralkyl, substituted aralkyl, heteroaryl, substituted heteroaryl, heterocycloalkyl or substituted heterocycloalkyl； with the proviso that when X is halo, nitro or cyano, R2 is absent, and when Y is halo, nitro or cyano, R3 is absent； R6 is H, alkyl, substituted alkyl, aryl, substituted aryl, heterocycle, substituted heterocycle, NR7R8, OR9 or halogen； R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R21, R24, R25, R26, R27, R28, R29, R30, R31, R32, R34, R35, R36, R38, R39 and R40 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycle or substituted heterocycle； R22, R23, R33 and R37 are independently selected from the group that it consists of alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycle or substituted heterocycle； R42 is (R43) n in which n is equal to 0, 1 or 2 and each R43 is independently selected from the group consisting of hydrogen, fluorine, chlorine and methyl； and R44 is methyl or hydrogen, with the additional conditions that: a. R2 may not be hydrogen if Y is SO, SO2, NR13CO2 or NR14SO2； and b. R3 may not be hydrogen if Y is SO, SO2, NR13CO2 or NR14SO2； or an enantiomer, diastereomer, or pharmaceutically acceptable salt or solvate thereof.Un compuesto of
