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Glutaminase inhibitors and methods of use
专利权人:
Agios Pharmaceuticals; Inc.
发明人:
LEMIEUX, Rene,POPOVICI-MULLER, Janeta,SALITURO, Francesco,SAUNDERS, Jeffrey,TRAVINS, Jeremy,YAN, Shunqi
申请号:
ES13808311
公开号:
ES2761951T3
申请日:
2013.11.21
申请国别(地区):
ES
年份:
2020
代理人:
摘要:
A compound of Formula (II) or a pharmaceutically acceptable salt thereof, wherein: ** Formula ** X is -S (O) - or -SO2-; each R1 and R2 is independently C1-6 alkylene-R4, -N (R3) -C (O) -R4, -C (O) -N (R3) -R4, -N (R3) -C (O) - O-R4, -N (R3) - C (O) -N (R3) -R4, -OC (O) -N (R3) -R4, -N (R3) -C (O) -C 1-6 alkylene -C (O) -R4 or -N (R3) -C (O) -C 1-6alkylene-N (R3) -C (O) -R4; each R3 is independently hydrogen, C1-6 alkyl or aryl; each R4 is independently C1-6 alkyl, C1-6 alkenyl, aryl, heteroaryl, aralkyl, heteroaralkyl, heterocyclylalkyl, heterocyclyl, cycloalkyl, or cycloalkylalkyl, each of which is substituted with 0-3 occurrences of R5, or two adjacent R5 moieties taken together with the carbon atoms to which they are attached, they form a heterocyclyl, heteroaryl, cycloalkyl, or aryl; each R5 is independently oxo (= O), C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, cyano, halo, -OH, -SH, -OCF3, - SO2-C1-6 alkyl, -NO2, - N (R7) -C (O) -C 1-6 alkyl, -N (R6) 2, -OC (O) -C 1-6 alkyl, C 3-7 cycloalkyl, (C 3-7 cycloalkyl) alkyl, aryl, aryloxy, -C (O) -aryl, heteroaryl, aralkyl, heteroaralkyl, heterocyclylalkyl or heterocyclyl, wherein each aryl, heteroaryl, or heterocyclyl is further substituted with 0-3 occurrences of R7; each R6 is independently hydrogen, fluoro, OH, or C1-6 alkyl; each R7 is independently hydrogen, C1-6 alkyl, -OH, -SH, cyano, halo, -CF3, -OCF3, -SO2-C1-6 alkyl, -NO2, -N (R6) -C (O) -alkyl C1-6, -N (R6) 2 or C1-6 alkoxy; m is 1, 2, or 3; and n is 1, 2 or 3; provided that the sum of m and n is 2 to 4, wherein the term "aralkyl" refers to an alkyl moiety in which a hydrogen atom is replaced by an aryl group, wherein the term "aryl "refers to a monocyclic, bicyclic, or tricyclic aromatic hydrocarbon ring system, wherein the term" cycloalkyl "includes cyclic, bicyclic, tricyclic, or polycyclic non-aromatic hydrocarbon groups having 3 to 12 carbons, wherein the term "Cycloalkylalkyl" refers to an alkyl group substituted with a cycloalkyl group, wherein the t
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