Phenoxypyridinyl amide derivatives and their use in the treatment of pathological conditions mediated by PDE4

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专利权人:

ASTRAZENECA AB

发明人:

ANDREWS, GLEN,COX, RHONA JANE,DE SAVI, CHRISTOPHER,MEGHANI, PREMJI,SANGANEE, HITESH JAYANTILAL,WARNER, DANIEL JON

申请号：

ES09754139

公开号：

ES2502527T3

申请日:

2009.05.26

申请国别(地区):

ES

年份:

2014

代理人:

摘要：

A compound of the formula (I): ** Formula ** where: R1 is NR7C (O) R8, NR5 7S (O) 2R8 or NR9R10； R2 is hydrogen or C1-6 alkyl； R3 is hydrogen, halogen, C1-4 alkyl or C1-4 alkoxy； R4 is hydrogen, halogen, cyano, hydroxy, C1-4 alkyl, C1-4 alkoxy, CF3, OCF3, C1-4 alkylthio, S (O) (C1-4 alkyl), S (O) 2 (C1-4 alkyl ), CO2H or CO2 (C1-4 alkyl)； R5 is methyl, ethyl or propyl substituted by piperidinyl, piperazinyl, morpholinyl, homomorpholinyl or homopiperazinyl； R6 is hydrogen, halogen, cyano, hydroxy, SH, CF3, OCF3, C (O) H, C1-6 alkylthio, S (O) (C1-6 alkyl), S (O) 2 (C1-6 alkyl), CO2H, CO2 (C1-6 alkyl), NR13R14, C1-6 alkyl (optionally substituted by halogen, OH, CO2H, NR15R16, NHC (O) O (C1-6 alkyl), OS (O) 2 (C1-6 alkyl ) or heterocyclyl), C1-6 alkoxy (optionally substituted by halogen, OH, CO2H, NR15R16 or heterocyclyl), C3-6 cycloalkyl (optionally substituted by halogen, OH, CO2H, NR15R16 or heterocyclyl) or heterocyclyl； R7 is hydrogen or C1-6 alkyl (optionally substituted by NR26R27)； R8 is C1-6 alkyl {optionally substituted by hydroxyl, C1-6 alkoxy, NR21R22, heterocyclyl {optionally substituted by oxo, hydroxy, C1-6 alkyl, CO2 (C1-6 alkyl), aryl, heteroaryl, aryl (C1-4 alkyl), heterocyclyl or C (O) (C1-4 alkyl) phenyl}, aryl, heteroaryl, C3-7 cycloalkyl, C3-7 cycloalkyl (C1-4 alkyl), CO2H, CO2 (C1-6 alkyl), aryl ( C1-4 alkoxy), aryl (C1-4 alkylthio), S (O) 2 (C1-6 alkyl), NHC (O) heteroaryl or NHC (O) R2320}, C1-6 alkoxy, C3-6 cycloalkyl {optionally hydroxy substituted, NR24R25 or C1-6 alkyl}, heterocyclyl {optionally substituted by oxo, hydroxy, C1-6 alkyl, amino, aryl, heteroaryl, aryl (C1-4 alkyl), heteroaryl (C1-4 alkyl), heterocyclyl or C (O) (C1-4 alkyl) phenyl}, aryl (C1-4 alkyl) {substituted by amino (C1-4 alkyl)}, aryl or heteroaryl； R9 is hydrogen, C1-6 alkyl (optionally substituted by aryl or heteroaryl), aryl or heteroaryl； R10 is hydrogen, C1-6 alkyl (optionally substituted by hydroxyl, C1-6 alkoxy, aryl, aryloxy, phenyl (C1-6 alkoxy), heteroaryl, C3

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