NAIMISHA TRIVEDI,CHARLES BAKER-GLENN,HERV VAN DE POL,WESLEY BLACKABY,ELISABETTA ARMANI,GABRIELE AMARI
申请号：
ARP160101282
公开号：
AR104532A1
申请日:
2016.05.05
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
Compounds that are both phosphodiesterase 4 enzyme (PDE4) inhibitors and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them, and therapeutic use. Claim 1: A compound characterized in that it is of general formula (1) where: each R¹ is hydrogen or is independently selected from the group consisting of: halogen, C₁₋₄ alkyl, C₁₋₄ alkoxy, C₁₋₄ haloalkyl, hydroxy , -SO₂NR⁶R⁷,-Cn, - No. 831222； - No. 183228313；-8310； 8311；-CONR⁶R⁷ and -NR⁸COR⁹ and wherein said C₁₋₄ alkyl is optionally substituted with one or more groups selected from C₃₋₇ cycloalkyl, hydroxy and -NR⁶R⁷ and where said C₁₋₄ alkoxy is optionally substituted with one or more halogens or C₃₋ groups ₇ cycloalkyl where, R⁶ is hydrogen or C₁₋₆ alkyl； R⁷ is hydrogen or C₁₋₆ alkyl； R⁸ is hydrogen or C₁₋₆ alkyl； R⁹ is hydrogen or C₁₋₆ alkyl； n is an integer in the range of 1 to 3； each R² is hydrogen or is selected from the group consisting of: halogen, C₁₋₄ alkyl, C₁₋₄ alkoxy, C₁₋₄ haloalkyl, hydroxy, -SO₂NR¹⁰R¹¹,-CN and -NR¹²SO₂R¹³ and where said C₁₋₄ alkyl and said C₁₋₄ alkoxy are optionally substituted with one or more C₃₋₇ cycloalkyl groups where R¹⁰ is hydrogen or C₁₋₆ alkyl； R¹¹ is hydrogen or C₁₋₆ alkyl； R¹² is hydrogen or C₁₋₆ alkyl； R¹³ is hydrogen or C₁₋₆ alkyl； m is an integer in the range of 1 to 3； R³ and R⁴ are different or the same and are independently selected from the group consisting of: H, C₃₋₇ cycloalkylcarbonyl, C₁₋₆ alkyl, optionally substituted with one or more substituents selected from C₁₋₄ alkoxy, C₃₋₇ cycloalkyl or C₅₋₇ cycloalkenyl,C₁₋₆ haloalkyl, C₃₋₇ cycloalkyl, C₅₋₇ cycloalkenyl, C₂₋₆ alkenyl, and C₂₋₆ alkynyl； each R⁵,When attending the meeting, they shall be selected independently from the following groups:Cf.8323 and halogen atoms； K is an integer of level 0 or 1 to 3； L1 is a link； W1 is selected from a divergent arileno and a pagan group； W2 is selected from an arilo and a pagan group； L2 is an integer of level 1 to 4 selected f
