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CDC7 kinase inhibitors and their uses
专利权人:
Sloan Kettering Institute For Cancer Research
发明人:
FRATTINI, Mark,DJABALLAH, Hakim,KELLY, Thomas
申请号:
ES11709276
公开号:
ES2661367T3
申请日:
2011.03.08
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of Formula (A) or (B): ** (See formula) ** or a pharmaceutically acceptable salt thereof, wherein: each case of R1 and R4 is independently selected from the group consisting of hydrogen, carbonyl , silyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl and optionally substituted heteroaryl; each case of R2 and R3 is independently selected from the group consisting of hydrogen, halogen, -OH, substituted hydroxyl, -SH, substituted thiol, -NH2, substituted amino, - CN, -NO2, carbonyl, silyl, sulfinyl, sulfonyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl and optionally substituted heteroaryl; or R2 and R3 are linked to form an optionally substituted carbocyclyl group or optionally substituted heterocyclyl; R5 is hydrogen; R6 is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl and optionally substituted heteroaryl; R7 is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl and optionally substituted heteroaryl; R12 is selected from the group consisting of hydrogen, carbonyl, silyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl and optionally substituted heteroaryl; R13 is selected from the group consisting of halogen, -OH, substituted hydroxyl,
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