The present invention is directed to aziridinyl epothilone compounds as further described herein, and/or pharmaceutically-acceptable salts and/or solvates thereof having the following Formula: wherein K is &mdash；O&mdash；, &mdash；S&mdash；, or &mdash；NR7&mdash；； A is &mdash；(CR8R9)&mdash；(CH2)m&mdash；Z&mdash；wherein Z is &mdash；(CHR10)&mdash；, &mdash；C(&boxH；O)&mdash；, &mdash；C(&boxH；O)&mdash；C(&boxH；O)&mdash；, &mdash；OC(&boxH；O)&mdash；, &mdash；N(R11)C(&boxH；O)&mdash；, &mdash；SO2&mdash；, or &mdash；N(R11)SO2&mdash；； B1 is hydroxyl or cyano and R1 is hydrogen or B1 and R1 are taken together to form a double bond； R2, R3, and R5 are, independently, hydrogen, alkyl, substituted alkyl, aryl or substituted aryl； or R2 and R3 may be taken together with the carbon to which they are attached to form an optionally substituted cycloalkyl； R4 is hydrogen, alkyl, alkenyl, substituted alkyl, substituted alkenyl, aryl, or substituted aryl； R6 is hydrogen, alkyl or substituted alkyl； R7, R8, R9, R10, R11 and R12 are independently hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heterocycloalkyl, substituted heterocycloalkyl, heteroaryl, or substituted heteroaryl； and R13 is aryl, substituted aryl, heteroaryl or substituted heteroaryl.본 발명은 화학식 X를 갖는 아지리디닐 에포틸론 화합물 (본원에 보다 상세하게 기재되어 있음) 및/또는 이들의 제약상 허용되는 염 및/또는 용매화물에 관한 것이다. 이들 화합물은 암 치료에서 표적화된 약물 전달을 위한 컨쥬게이트, 특히 폴레이트의 제조에 사용될 수 있다.<；화학식 X>；
