ДУТТ Чайтаня (IN),ДЖОШИ Дипа (IN),ГУПТА Рам (IN),ЧАНДРА Кумарпрафулл (IN)
申请号：
RU2010135524/15
公开号：
RU2010135524A
申请日:
2009.01.21
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A pharmaceutical combination comprising a compound represented by formula (I) or a pharmaceutically acceptable salt thereof:! . ! where! R1 is —R4 — R5 or —N (R7) N (R7) R9； ! R4 is selected from the group consisting of —N (R7) R6O—, —N (R7) R6N (R7) -, OR6O and —OR6N (R7) -, where R6 is alkyl with C2-C8 carbon atoms； R5 is selected from the group consisting of alkyl, aryl, including heteroaryl, —COR7, SO2R7, —C (S) NHR7, —C (NH) NHR7, —COR10,! ! where R7 is selected from the group consisting of H, alkyl and aryl, including heteroaryl, provided that R7 may be the same or different for R1 and R3 in the same compound； ! R2 is selected from the group consisting of F, Cl, Br, I, OR7, NO2, alkyl, aryl, including heteroaryl, formyl, acyl, C (O) NR7R10, C (O) OR7, NR7R10, N = C (R7) (R10), SR7, SO2NH2, SO2-alkyl and SO2-aryl, and m is 0, 1 or 2； ! R3 is selected from the group consisting of R7, OR7, N (R7) (R10), N = C (R7) (R10), N (R7) N (R7) (R10), N (R7) N = C (R7 ) (R10) and CH (R7) C (O) R8； ! where R8 is selected from the group consisting of R7, OR7 and NR7R10； ! R9 is selected from the group consisting of hydrogen, alkyl, aryl, including heteroaryl, C (O) R10, -SO2R10, -C (S) NHR10, -C (NH) NH (R10) and -C (O) NHR10,! R10 is selected from the group consisting of H, alkyl or aryl, including heteroaryl, and in each case may be the same with or different from R7, provided that R10 may be the same or different for R1 and R3 in the same compound； ! X is selected from the group consisting of halide ion, acetate ion, perchlorate ion, sulfonate ion, oxalate ion, citrate ion, tosylate ion, maleate ion, mesylate ion, carbonate ion, sulfite ion hydrophosphate ion, phosphonate ion, phosphate ion, BF4 - and PF6 - or zero； provided that, ! (i) when two alkyl groups are present on the same carbon or nitrogen, they can be bonded together to form a cyclic structure； ! (ii) heteroaryl nitrogen1. Фармацевтическая комбинация, содержащая соединение, представленное формулой (I), или
