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2-amino-4-phenyl-dihydroquinolines substituted, procedure for its preparation, its use as a medicine as well as medicine containing them
专利权人:
SANOFI
发明人:
LANG, HANS-JOCHEN,WESTON, JOHN,HEINELT, UWE
申请号:
ES07723091
公开号:
ES2543345T3
申请日:
2007.03.08
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
Compounds of the formula I ** Formula ** where they mean: R1, R2, R3 and R4, independently of each other, hydrogen, F, Cl, Br, I, CN, NO2, CF3, CH3-SO2, alkyl with 1 , 2, 3 or 4 atoms of C, NH2, NH-CH3 or N (CH3) 2; R5 and R6, independently of each other, hydrogen, alkyl with 1, 2, 3, 4, 5 or 6 C atoms, CF3-CH2-, cycloalkyl with 3, 4, 5 or 6 C atoms or cyclopropyl-CH2-, or R5 and R6 together with the nitrogen atom to which they are attached, a ring of 4, 5, 6, 7, 8, 9 or 10 members, in which one or two CH2 groups can be replaced, independently of one of another, for NR12, sulfur, oxygen, C (O) or SO2; R12 hydrogen, alkyl with 1, 2, 3 or 4 C atoms or cycloalkyl with 3, 4, 5 or 6 C atoms; R7 hydrogen or alkyl with 1, 2, 3 or 4 C atoms; R8 and R9, independently of one another, hydrogen, F, Cl, Br, OH, alkyl with 1, 2, 3 or 4 atoms of C, CH3O, CF3 or CH3SO2; R10 and R11, independently of each other, R13- (CmH2m) -Bn, where m zero, 1, 2, 3 or 4; n zero or 1; B -CO-, -CONR14- or -SO2-; R14 hydrogen or alkyl with 1, 2, 3, 4, 5 or 6 C atoms; R13 hydrogen, alkyl with 1, 2, 3 or 4 C atoms, cycloalkyl with 3, 4, 5 or 6 C atoms, 1- pyrrolidinyl, 1-piperidinyl, 1- (4-methylpiperazinyl), 1-morpholinyl, - COOR15, OR16, NR17R18 or phenyl which, independently of one another, carries 1 or 2 substituents chosen from the group of chlorine, fluorine, methyl and methoxy; R15, R16, R17 and R18, independently of one another, hydrogen or alkyl with 1, 2, 3, 4, 5 or 6 C atoms; or R10 and R11 form, together with the nitrogen atom to which they are attached, a ring of 4, 5, 6, 7, 8, 9 or 10 members, in which one, two or three CH2 groups can be replaced, independently from one another, by NR19, sulfur, oxygen C (O) or SO2; R19 hydrogen, alkyl with 1, 2, 3 or 4 C atoms or cycloalkyl with 3, 4, 5 or 6 C atoms; as well as its pharmaceutically compatible salts and trifluoroacetates.Compuestos de la fórmula I**Fórmula** en donde significan: R1, R2, R3 y R4, independientemente uno de otro, hidrógeno,
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