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Compuestos antimicrobianos/adyuvantes
专利权人:
Denovamed Inc.
发明人:
WU, Fan,LU, Erhu,BARDEN, Christopher J.
申请号:
ES12752962
公开号:
ES2583093T3
申请日:
2012.03.02
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A compound having a pharmaceutically acceptable ring containing sulfur, or salts thereof, of Formulas I: ** ** formulas wherein E is -CH2- or absent, in which case the sulfur containing ring is connected directly to phenyl R1, R2, R9, R10, and R11 if present are each independently selected from the group consisting of hydrogen, methyl, ethyl, propyl, cyclopropyl, butyl, cyclobutyl, pentyl, hexyl, isopropyl, isobutyl, neopentyl, methoxy, and ethoxy further, R1 and R2 may be connected to form a phenyl ring or benzofuran further, R9 and R10 may be connected to form a phenyl ring or benzofuran R3 and R8 are each independently selected from the group consisting of hydrogen, methyl, ethyl, propyl, isopropyl, chloro, fluoro, tert-butyl, methoxy, and ethoxy R4 and R7 are each independently selected from the group consisting of hydrogen ,, chlorine, methyl ester, ethyl ester, methyl, ethyl, propyl, cyclopropyl, butyl, cyclobutyl, isopropyl, isobutyl, methoxy, and ethoxy and R5 and R6 are each independently selected from the group consisting of hydrogen, cyclopentyl, cyclopropyl, furan, thiophene, trifluoromethyl, trifluorometílico ether, methylthiol, formaldehyde, chlorine, fluorine, bromine, phenyl, methyl, ethyl, isopropyl, propyl, butyl , cyclobutyl, isobutyl, neopentyl, pentyl, methoxy, and ethoxy.Un compuesto que tiene un anillo que contiene azufre, o sales farmacéuticamente aceptables del mismo, de una de las Fórmulas I:**Fórmulas** en las que E es -CH2- o está ausente, en cuyo caso el anillo que contiene azufre está conectado directamente a fenilo R1, R2, R9, R10, y R11 si está presente se seleccionan independientemente cada uno del grupo que consiste en hidrógeno, metilo, etilo, propilo, ciclopropilo, butilo, ciclobutilo, pentilo, hexilo, isopropilo, isobutilo, neopentilo, metoxi, y etoxi adicionalmente, R1 y R2 pueden conectarse para formar un anillo de fenilo o benzofurano adicionalmente, R9 y R10 pueden conectarse para formar un anillo de fenilo o benzofurano R3 y
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