FIELD: pharmaceutics.SUBSTANCE: invention relates to a compound of the following formula (I): [Chem. 1],wherein A is phenyl or 6-membered heteroaryl containing 1 to 2 heteroatoms of N； B is selected from the group consisting of -C1-6 alkylene-NR2-, -NR2- and -(C=O)-； C is selected from the group consisting of -(C=O)- and -NR2-； R1 is independently selected from the group consisting of: (2) -On-C1-6 alkyl wherein alkyl is unsubstituted or substituted by one or more substituents independently selected from R11, (3) -On-C3-7 cycloalkyl, where cycloalkyl is unsubstituted, (4) -On-phenyl, wherein phenyl is unsubstituted or is substituted by one or more substituents independently selected from R11, (6) -S-phenyl, wherein phenyl is unsubstituted or is substituted by one or more substituents independently selected from R11； (7) -NH-C1-6 alkyl wherein alkyl is unsubstituted or substituted by one or more substituents independently selected from R11, and (9) -On- (5-membered heteroaryl containing 1-2 heteroatoms selected from N), wherein heteroaryl is unsubstituted or substituted by one or more substituents independently selected from R11； R2 are independently selected from the group consisting of: (1) hydrogen, (2) halogen selected from chlorine, bromine and fluorine, (4) -On-C1-6 alkyl, (8) -On-(6-membered heterocyclyl containing 1 N atom), wherein heterocyclyl is unsubstituted or is substituted by one or more substituents independently selected from R7, (9) -(C=O)-NR8R9 and (10) -NR8R9； R3 and R4 are independently hydrogen or C1-6 alkyl； R5 are independently selected from the group consisting of: (1) hydrogen and (3) -On-C1-6 alkyl； R6 is independently hydrogen, C1-6 alkyl, C1-6 alkoxy, C3-7 cycloalkyl, -NR8R9, 4-6 membered heterocyclyl containing 1-2 heteroatoms selected from N and O, phenyl, 5-6 membered heteroaryl containing 1-2 heteroatoms selected from N, O and S, phenyl-C1-6 alkyl, (5-membered heteroaryl containing 2-3 heteroatoms selected from N) -C1-6alkyl or (6-mem
