ESHVELL Mark A. (US),ЭШВЕЛЛ Марк А. (US),BRASSARD Kris (US),БРАССАРД Крис (US),FAJLIKOV Anton (US),ФАЙЛИКОВ Антон (US),KHILL Dzhejson (US),ХИЛЛ Джейсон (US),KERNER Shteffi (US),КЕРНЕР Штеффи (US),LAPE,ESHVELL Mark A.,ЭШВЕЛЛ Марк А.,BRASSARD Kris,БРАССАРД Крис,FAJLIKOV Anton,ФАЙЛИКОВ Антон,KHILL Dzhejson,ХИЛЛ Джейсон,KERNER Shteffi,КЕРНЕР Штеффи,LAPERR Zhan-Mark,ЛАПЬЕРР Жан-Марк,LYU Yanbin,ЛЮ Яньбин
申请号：
RU2012132444
公开号：
RU0002619463C2
申请日:
2010.12.29
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to a heterocyclic compound of formula (I) or a pharmaceutically acceptable salt or ester, wherein X1: N and X2: CRx； Rx, R1 and R3: H, halogen, nitro, C1-C6alkyl, C1-C6alkyl, substituted by three halogen atoms, C1-C6alkoxy, amino, C6-C10-aryl, C6-C10-aryl substituted by 1-2 substituents selected from hydroxyl, halogen, cyano, amino, di-C1-C6alkilamino, C1-C6alkyl, C1-C6alkyl substituted by hydroxyl or amino, C1-C6alkoxy, C1-C6alkoxy substituted by three halogen atoms, C1-C6alkilkarbonyl, C1-C6alkoxykarbonyl, carboxyl, aminocarbonyl, C1-C6alkilaminokarbonyl, C1-C6alkilkarbonylamino, C1-C6alkilsulfinyl, 5-x heteroaryl containing 2 atom of N, and 5-x or 6-x heterocycle Containing 1-2 heteroatoms selected from N and O, Heteroaryl containing one or two 5-x or 6-x rings and 1-2 heteroatoms selected from N, O and S, heteroaryl containing one or two 5-x or 6-x rings and 1-2 heteroatoms selected from N and O, substituted by 1 or more substituents selected from hydroxyl, halogen, amino, C1-C6alkylcarbonyl, carboxyl, C1-C6alkyl and a 6-x heterocycle containing 2 heteroatoms selected from N and O, C3-C6 saturated carbocycle or 6-membered A heterocycle containing 1 N atom； X or y is 0 or 1； Rp1: halogen； Rp2: C1-C6alkyl or 5-x heteroaryl containing 2 heteroatoms selected from N and O； Rn5 and Rn6: H or S(O)2R8； R8: H or C1-C6alkyl； R: H, halogen, C1-C6alkyl, C1-C6alkyl, substituted by amino, C1-C6alkoxy, amino, 5-x heteroaryl containing 2-3 heteroatoms selected from N, C3-C6saturated carbocycle, C3-C6 saturated carbocycle substituted by one A substituent selected from amino, C1-C6alkoxycarbonyl, C1-C6alkylaminocarbonyl, carboxyl, and aminocarbonyl, a heterocycle containing one 4-x or 6-x ring and 1-2 heteroatoms selected from N, A heterocycle containing one 4-, 5-x or 6-x ring and 1-2 heteroatoms selected from N, O and S substituted with one substituent selected from methyl and amino or Q-T； Q: connection or C1-C6alkyl linker； T: NRn
