CHAJLDERS Mettyu Llojd (US),ЧАЙЛДЕРС Мэттью Ллойд (US),DINSMOR Kristofer (US),ДИНСМОР Кристофер (US),FULLER Piter (US),ФУЛЛЕР Питер (US),GERIN Devid (US),ГЕРИН Дэвид (US),KATTS Dzhejson Devid (US),КАТ,CHAJLDERS Mettyu Llojd,ЧАЙЛДЕРС Мэттью Ллойд,DINSMOR Kristofer,ДИНСМОР Кристофер,FULLER Piter,ФУЛЛЕР Питер,GERIN Devid,ГЕРИН Дэвид,KATTS Dzhejson Devid,КАТЦ Джейсон Дэвид,PU Tsinlin,ПУ Цинлинь,SKOTT M
申请号：
RU2015144386
公开号：
RU0002655380C2
申请日:
2014.03.19
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
FIELD: organic chemistry.SUBSTANCE: invention relates to organic chemistry, specifically to a compound of formula I or a pharmaceutically acceptable salt thereof (I),where A is selected from phenyl, isoindolinyl, quinolinyl, pyridinyl,,2,3-dihydro-1H-indenyl, benzothazolyl and 1,2,3,4-tetrahydroisoquinolinyl； n is 0, 1, 2, or 3； m is 0, 1, 2, or 3； p is 2, 3, or 4； R1 is selected from: halogen, oxo(=O), C1-6alkyl(oxy)0-1(carbonyl)0-1C1-6alkyl, C3-6cycloalkylC0-6alkyl, heteroaryl (carbonyl)0-1C0-6alkyl, where heteroaryl is a 5–6 membered ring containing 1–3 heteroatoms selected from nitrogen, nitrogen and oxygen, and nitrogen and sulphur, (C3-12)heterocycloalkyl(carbonyl)0-1C0-6alkyl, where the 3–12 membered heterocycloalkyl contains 1–2 heteroatoms selected from nitrogen, oxygen, nitrogen, sulphur, nitrogen and oxygen, and oxygen and sulphur, C1-6alkyl(oxy)1(carbonyl)1aminoC1-6alkyl, heteroaryl(carbonyl)1aminoC1-6alkyl, where heteroaryl is a 5–6 membered ring containing 1–2 heteroatoms selected from nitrogen and oxygen, C0-6alkylamino(carbonyl)0-1C1-6alkyl, heteroarylamino(carbonyl)1C1-6alkyl, wherein heteroaryl is a 5-membered ring containing 1–2 heteroatoms selected from nitrogen, C1-6alkylsulfonyl, (C3-6)cycloheteroalkylsulfonylC0-6alkyl, where cycloheteroalkyl contains 1–2 heteroatoms selected from nitrogen and oxygen, C1-6alkylsulfonimidoyl, C1-6alkylthioC1-6alkyl, -CO2H, -SO2NH2, -SO2NH(C1-6alkyl), -SO2N(C1-6alkyl)2, -(C1-6alkyl)OH, -C1-6alkylalkoxy, cyano, and C1-6haloalkyl； and where two R1 may optionally bind to ring atoms to which they are attached to form a 3 to 6-membered ring； R2 is selected from: halogen, C1-6alkyl, (C3-6)heterocycloalkyl, where heterocycloalkyl contains 1 nitrogen heteroatom, C3-6cycloalkylC1-6alkylamino, (C1-6alkyl)1-2amino, and hydroxy, where two R2 may optionally be bound to a ring atom to which each is attached to form a 3–6 membered saturated ring； and where R1 and R2 each is optionally substituted with 1, 2, 3 or 4 substituents
