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Piperazinyl pyrimidine derivatives, preparation method and its use
专利权人:
Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China;Peking University
发明人:
LI, Song,WANG, Ying,XIAO, Junhai,MA, Dalong,GONG, Hongwei,QI, Hui,WANG, Lili,LING, Xiaomei,ZHENG, Zhibing,ZHANG, Yang,ZHONG, Wu,LI, Meina,XIE, Yunde,XU, Enquan,LI, Xingzhou,MA, Jing,ZHAO, Guoming,ZHOU
申请号:
ES13738361
公开号:
ES2621901T3
申请日:
2013.01.15
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of formula I, ** Formula ** wherein: any two of A, B and D are N and the other is CH; Z is selected from the group consisting of -CH2-, -C (O) - and -S (O) 2-; X is halogen or N, with the proviso that when X is halogen, R1 and R2 in formula I are absent; R1 and R2 are each independently selected from the group consisting of H, linear or branched alkyl having 1 to 6 carbon atoms, linear or branched C1-C6 heteroalkyl containing 1 to 2 heteroatoms selected independently from the group consisting of O , N and S; or R1 and R2, together with N to which they are attached, form a 5-8 membered heterocycloalkyl containing 1 to 2 heteroatoms selected independently from the group consisting of O, N and S; R3 and R4 are each independently selected from the group consisting of H, aryl, heteroaryl, fused aryl, or fused heteroaryl containing 5 to 10 atoms; wherein said aryl, heteroaryl, fused aryl, or fused heteroaryl is optionally and independently mono-, di-, or poly-substituted with a substituent selected from the group consisting of halogen, cyano, trifluoromethyl, hydroxy, and nitro; R5 is selected from the group consisting of linear or branched alkyl having 1 to 6 carbon atoms, linear or branched C1-C6 heteroalkyl containing 1 to 2 heteroatoms selected independently from the group consisting of O, N and S, cycloalkyl which contains 4 to 8 carbon atoms, 5 to 8 membered heterocycloalkyl containing 1 to 2 heteroatoms selected independently from the group consisting of O, N and S; m and n are each independently 0, 1 or 2; or a racemate or stereoisomer, or a pharmaceutically acceptable salt or solvate thereof.Un compuesto de fórmula I, **Fórmula** en la que: dos cualquiera de A, B y D son N y el otro es CH; Z se selecciona del grupo que consiste en -CH2-, -C(O)- y -S(O)2-; X es halógeno o N, con la condición de que cuando X es halógeno, R1 y R2 en la fórmula I están ausentes; R1 y R2 se seleccionan cada uno independientemente del grupo que consiste en H, alquilo lineal
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