FIELD: pharmaceutics.SUBSTANCE: invention relates to piperazinyl pyrimidine derivatives of formula I capable of antagonizing CCR4, method for production thereof, pharmaceutical compositions based thereon, the use of the compounds in the manufacture of a medicament, as well as to a method of treatment. In general formula I any two of A, B and D are N, and the other one is CH； Z is selected from the group consisting of -CH2-, -C(O)-； X is halogen or N, with the proviso that when X is halogen, R1 and R2 in formula I are absent； R1 and R2 are each independently selected from the group consisting of linear or branched alkyl having 1 to 6 carbon atoms, C1-C6 linear or branched heteroalkyl containing 1 to 2 heteroatoms independently selected from the group consisting of O； R3 and R4 are each independently selected from the group consisting of H, phenyl and naphthyl； said phenyl or naphthyl is optionally and independently mono-, di-or poly-substituted with a substituent selected from the group consisting of halogen； R5 is selected from the group consisting of linear or branched alkyl having 1 to 6 carbon atoms, C1-C6 linear or branched heteroalkyl containing 1 to 2 heteroatoms independently selected from the group consisting of S, cycloalkyl group containing 4 to 8 carbon atoms, 5- to 8-membered heterocycloalkyl containing 1 to 2 heteroatoms independently selected from the group consisting of N and S； m and n are each independently 0 or 1.EFFECT: piperazinyl pyrimidine derivatives of formula I capable of antagonizing CCR4 are proposed.7 cl, 2 tbl, 16 ex(I)Изобретение относится к производным пиперазинил пиримидина формулы I, обладающим антагонизмом к CCR4, способу их получения, фармацевтической композиции на их основе, их применению для изготовления лекарственного средства, а также к способу лечения. В общей формуле I любые два из А, В и D являются N, а оставшийся является СН； Z выбирают из группы, состоящей из -СН2- и -С(О)-； X представляет собой галоген или N, при условии,
