This document provides compounds, their compounds and their use. 1. Claim 1: a formula compound (1),Or one of its drug acceptable salts, wherein: A-ring is selected from 3-8 single periodic carbon rings with saturated or partially unsaturated members, phenyl, and 8-10 members of bicyclic carbon ring, A partially unsaturated monocyclic ring, consisting of 4-8 members, is independently selected by 1-2 heteroatoms selected from nitrogen, oxygen or sulfur, and matched with 5-6 aromatic rings, and 0-4 heteroatoms selected from nitrogen, oxygen or sulfur,A partially unsaturated, aperiodic spiral ring of 7-12 members, consisting of 1-2 heteroatoms independently selected from nitrogen, oxygen or sulfur, is a partially unsaturated aperiodic double ring of 7-12 members, consisting of 1-4 heteroatoms independently selected from nitrogen, One is composed of 7-12 partially unsaturated bicyclic aromatic rings, consisting of 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur, and one partially unsaturated bicyclic bridge consisting of 7-12 members and 1-2 selected heteroatoms,A monocyclic heteroaromatic ring consisting of 5-6 members is composed of 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur, and 8-10 members of a monocyclic heteroaromatic ring, consisting of 1-5 independent heteroatoms, Het is a single ring aperiodic ring composed of 4-8 members, which is composed of 1-2 heteroatoms independently selected from nitrogen, oxygen or sulfur. This is a saturated aperiodic ring composed of 7-12 members and 1-4 independent heteroatoms,Nitrogen, oxygen or sulfur, saturated bicyclic aperiodic ring composed of 7-12 members, 1-3 heteroatoms independently selected from nitrogen, oxygen or sulfur, or saturated ring aperiodic ring composed of 7-12 members, and 1-2 independently selected heteroatoms, a. Nitrogen, oxygen or sulfur； ring B is a compound selected from the formula set (2)；The ring is selected from the formula (3)；a. Each R is an indepe
