MAK GOUEN DEHVID,МАК ГОУЕН Дэвид,DEMEHN SAMJUEHL DOMINIK,ДЕМЭН Самюэль Доминик,LAST STEFAN ZHJULEN,ЛАСТ Стефан Жюльен,VANDIK KOEHN,ВАНДИК Коэн,RABUASSON PER ZHAN-MARI BERNAR,РАБУАССОН Пьер Жан-Мари Бе
申请号：
RU2012108629/04
公开号：
RU0002538507C2
申请日:
2010.08.06
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to heterocyclic compounds of general formula Ior to pharmaceutically acceptable salts or solvates or stereoisomers thereof, where R and R* are each independently -CR1R2R3, C1-4alkylamino, benzylamino, C6-10arylamino, heteroC4-7cycloalkyl containing 1 heteroatom selected from O where R1 is selected from C1-4alkyl phenyl, optionally substituted with 1, 2 or 3 substitutes independently selected from halogen, C1-4alkyl, C1-4alkoxy, trifluoromethoxy or 2 substitutes at neighbouring ring atoms, which form a 1,3-dixolane group benzyl, optionally substituted with a halogen or methoxy phenylsulphonylmethyl C3-5heteroaryl containing 1 to 2 heteroatoms independently selected from N and O C3-5heteroarylmethyl containing 1 to 2 heteroatoms selected from N and C3-6cycloalkyl R2 is selected from hydrogen, hydroxyl, di-C1-4alkylamino, C1-4alkylcarbonylamino, C1-4alkyloxycarbonylamino, C1-4alkylaminocarbonylamino, piperidin-1-yl or imidazol-1-yl R3 is hydrogen or, alternatively, R2 and R3 together form an oxo group or R1 and R3 together form cyclopropyl under the condition that if one of R and R* is -CH(C6H5)N(CH3)2, the other cannot be -CH(C6H5)NHC(=O)OCH3 and if R and R* are identical, R1 is not phenyl, when R2 is hydroxyl, acetylamino, methoxycarbonylamino or tert-butoxycarbonylamino, and R3 is hydrogen and R1 is not C1-4alkyl, when R2 is C1-4alkyloxycarbonylamino, and R3 is hydrogen. The invention also relates to a pharmaceutical composition based a compound of formula I and use thereof.EFFECT: obtaining novel compounds which are useful in preventing or treating HCV infection.9 cl, 2 tbl, 3 exИзобретение относится к области органической химии, а именно к гетероциклическим соединениям общей формулы I или к их фармацевтически приемлемым солям, или сольватам, или их стереоизомерам, где R и R*, каждый независимо, представляет собой -CR1R2R3, C1-4алкиламино, бензиламино, C6-10ариламино, гетероС4-7циклоалкил, содержащий 1 гетероатом, выбра
