您的位置: 首页 > 农业专利 > 详情页

SUBSTITUTED PYRIDOPYRAZINES AS NOVEL SYK INHIBITORS
专利权人:
HUTCHISON MEDIPHARMA LIMITED
发明人:
SU Wei-Guo (CN),СУ Вэй-Го (CN),DENG Wei (CN),ДЭН Вэй (CN),JI Jianguo (CN),ЦЗИ Цзяньго (CN),SU WEI-GUO,СУ Вэй-Го,DENG WEI,ДЭН Вэй,JI JIANGUO,ЦЗИ Цзяньго
申请号:
RU2013158996/04
公开号:
RU0002569635C9
申请日:
2012.06.07
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: invention relates to compounds of formula (I), their racemic mixture, enantiomers, diastereomers and pharmaceutically acceptable salts, possessing properties of Syk inhibitor, pharmaceutical composition and medication based thereof, thereof application, methods of inhibiting and method of treatment with thereof application. In general formula (I) R1 represents hydrogen or C1-C6alkyl, R2 represents phenyl, benzo[d][1,3]dioxolyl, 2,3-dihydrobenzo[b][1,4]dioxinyl, or 5-10-membered heteroaryl, containing 1-2 heteroatoms, selected from N and O, which is optionally substituted with one or several groups, selected from halogen, -NR5R6, -OR7, -S(O)nR8, -C(O)R9, -CN, -C(O)NR5R6, -NR5C(O)R9, -NR5S(O)nR8, -S(O)nNR5R6, C1-C6alkyl, optionally substituted with one, two or three groups, selected from halogen, -OH, -OC1-C4alkyl, -NH2, -NH(C1-C4alkyl), -N(C1-C4alkyl)(C1-C4alkyl), -C(O)N(C1-C4alkyl)(C1-C4alkyl), or 5-8-membered heterocycle, containing 1-2 heteroatoms, selected from N, O, and S, optionally substituted with -SO2(C1-C4alkyl), C3-C6cycloalkyl, 5-8-membered heterocycle, containing 1-2 heteroatoms, selected from N, O and S, optionally substituted with one, two, or three groups, selected from halogen, -OH, C1-C4alkyl, -C1-C4alkyl-OH, ketogroup(oxo), -C(O)C1-C4alkyl, -C(O)C3-C6cycloalkyl, -C(O)C3-C6cycloalkyl-CN, -C(O)C3-C6cycloalkylhalogen, -C(O)NH2, -C(O)NH(C1-C4alkyl), -C(O)N(C1-C4alkyl)(C1-C4alkyl), -C(O)(C1-C4alkyl)-OH, -C(O)(C1-C4alkyl)-O(C1-C4alkyl), -C(O)C1-C4halogenalkyl, -C(O)(C1-C4alkyl)-CN, -C(O)(C1-C4alkyl)-C(O)NH2, -C(O)(C1-C4alkyl)C3-C6cycloalkyl, -C(O)(C1-C4alkyl)-oxetane, C(O)-furanyl, -C(O)-tetrahydrofuranyl, -C(O)(C1-C4alkyl)-SO2(C1-C4alkyl), -O(C1-C4alkyl)-OH, -SO2(C1-C4alkyl), -SO2NH(C1-C4alkyl), -SO2(C1-C4alkyl)(C1-C4alkyl), -SO2C3-C6cycloalkyl, -N(C1-C4alkyl)C(O)(C1-C4alkyl), and 5-6-membered heteroaryl, containing 1-2 nitrogen atoms, optionally substituted with C1-C4alkyl, R3 and R4 are independently selected from hydrogen
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充