HERVE BOUCHARD MARIE PRISCILLE,ALAIN COMMERCON,JODONG ZHANG
申请号：
HN2011003414
公开号：
HN2011003414A
申请日:
2011.12.28
申请国别(地区):
HN
年份:
2014
代理人:
摘要：
The present Invention relates to a selection Agent in the target which is attached at least one criptoficina Derivative of formula I,Wherein R1 represents a Halogen Atom and R2 represents an acyl Group of an amino acid or a derivative alcanoiloxi AA Group (C1 - C4)； R1 and R2 or bine together form a reason epoxide； AA indicates a natural or non natural amino acid； R3 represents alkyl group (C1 - C6 R4 and R5)； represent the S two H or together form a double Bond between CH = CH C13 and C14； R6 and R7 represent IndependentOne other ntemente H or an alkyl group (C1 - C6)； another one representandependientemente R8 and R9 H or an alkyl group (C1 - C6)； R10 represents at least a phenyl Substituent of the nucellus chosen between H: H, an Oh Group, alkoxy (c1-c4), or a Halogen Atom a Group, - NH2,- NH (alkyl (C1 - C6)； 2 R11 represents at least one of the core phenyl Substituent selected from H or an alkyl group (C - C4)； be United the selection Agent to the target and the Derivative of criptoficina covalently with the Union in Ortho position (or target) (m), (P) or Core Fen ILO bearer of CR1.LA PRESENTE INVENCION SE REFIERE A UN AGENTE DE SELECCION DE LA DIANA AL QUE ESTA UNIDO AL MENOS UN DERIVADO DE CRIPTOFICINA DE LA FORMULA I, EN LA QUE R1 REPRESENTA UN ATOMO DE HALOGENO Y R2 REPRESENTA UN GRUPO ACILO DERIVADO DE UN AMINOACIDO AA O UN GRUPO ALCANOILOXI (C1-C4)； O BINE R1 Y R2 FORMAN CONJUNTAMENTE UN MOTIVO EPOXIDO； AA INDICA UN AMINOACIDO NATURAL O NO NATURAL； R3 REPRESENTA UN GRUPO ALQUILO(C1-C6)； R4 Y R5 REPRESENTAN LOS DOS H O FORMAN CONJUNTAMENTE UN DOBLE ENLACE CH=CH ENTRE C13 Y C14； R6 Y R7 REPRESENTAN INDEPENDIENTEMENTE UNO DE OTRO H O UN GRUPO ALQUILO (C1-C6)； R8 Y R9 REPRESENTANDEPENDIENTEMENTE UNO DE OTRO H O UN GRUPO ALQUILO (C1-C6)； R10 REPRESENTA AL MENOS UN SUSTITUYENTE DEL NUCELO FENILO ELEGIDO ENTRE H: H, UN GRUPO OH, ALCOXI(C1-C4), UN ATOMO DE HALOGENO O BIEN UN GRUPO -NH2, -NH(ALQUILO(C1-C6))2； R11 REPRESENTA AL MENOS UN SUSTITUYENTE DEL NUCELO FENI
