The Invention relates to a selection of the target Agent is attached to at least one of criptoficina Derivative of formula (1), which represents a Halogen Atom, R1 and R2 represents an - Oh Group.An acyl group from Aminoacid AA or a group alcanoiloxi (c1-c4)； or R1 and R2 together form a reason ep u00d3xido Aminoacid； AA indicates natural or Unnatural； R3 represents alkyl group (C1 - C6)； R4 and R5 H represent the two together form a double Bond or CH = CH between C13 and C14； R6 and R7 represent independently of each other (H or an alkyl group (C1 - C6)； R8 and R9 reprIndependently of each other esentan H or an alkyl group (CI - C6)； River represents at least a Substituent of the phenyl Nucleus chosen from: H, an Oh Group, alkoxy (CI - C4), a Halogen Atom, or a Group, - NH2,- nhalquilo (C1 - C6) or N - (alkyl (C1 - C6)； 2 R11 represents at least a Substituent of the phenyl Nucleus selected from H or an alkyl group (C1 - C4)； being United, the selection of the target Agent and the Derivative of criptoficina covalently, situ u00c1ndose the Union Ortho or meta Position), (m) (P) or to the bearer of the phenyl Nucleus motive CR1LA INVENCIÓN SE REFIERE A UN AGENTE DE SELECCIÓN DE LA DIANA AL QUE ESTÁ UNIDO AL MENOS UN DERIVADO DE CRIPTOFICINA DE LA FÓRMULA (1), EN LA QUE: R1 REPRESENTA UN ÁTOMO DE HALÓGENO Y R2 REPRESENTA UN GRUPO -OH, UN GRUPO ACILO DERIVADO DE UN AMINOÁCIDO AA O UN GRUPO ALCANOILOXI(C1-C4)； O BIEN R1 Y R2 FORMAN CONJUNTAMENTE UN MOTIVO EPÓXIDO； AA INDICA UN AMINOÁCIDO NATURAL O NO NATURAL； R3 REPRESENTA UN GRUPO ALQUILO(C1-C6)； R4 Y R5 REPRESENTAN LOS DOS H O FORMAN CONJUNTAMENTE UN DOBLE ENLACE CH=CH ENTRE C13 Y C14； R6 Y R7 REPRESENTAN INDEPENDIENTEMENTE UNO DE OTRO H O UN GRUPO ALQUILO(C1-C6)； R8 Y R9 REPRESENTAN INDEPENDIENTEMENTE UNO DE OTRO H O UN GRUPO ALQUILO(CI-C6)； RIO REPRESENTA AL MENOS UN SUSTITUYENTE DEL NÚCLEO FENILO ELEGIDO ENTRE: H, UN GRUPO OH, ALCOXI(CI-C4), UN ÁTOMO DE HALÓGENO O BIEN UN GRUPO -NH2, -NHALQUILO(C1-C6) O -N(ALQUILO(C
