ACIDES (3R,4R,5S)-5-GUANIDINO-4-ACYLAMINO-3-(PENTAN-3-YLOXY)CYCLOHEXENE-1-CARBONIQUES SUBSTITUES EN FLUOR, LEURS ETHERS, ET PROCEDE D'UTILISATION

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专利权人:

IVACHTCHENKO, ALEXANDRE VASILEVICH;ASAVI, LLC

发明人:

IVACHTCHENKO, ALEXANDRE VASILEVICH

申请号：

CA2872733

公开号：

CA2872733C

申请日:

2013.05.07

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

The present invention relates to novel neuraminidase activity inhibitors anduse thereof forprophylaxis and treatment of influenza infection, that is, tofluorosubstituted4-acetamido-5-guanidino-3-(pentan-3-yloxy)cyclohex-1-enecarboxylic acids,their esters of the general formula 1, pharmaceutically acceptable saltsand/or hydrates thereof,(see formula 1)wherein R represents hydrogen, optionally substituted C1-C5alkyl, C2-C5alkenylor C2-C5alkynyl；Rf represents CH2F or CHF2.Pharmaceutical composition is given, method for its preparation, as well asmethod forprophylaxis and treatment of viral diseases.

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