Fluorine-substituted (3R, 4R, 5S) -5-guanidino-4-acetamido-3- (pentan-3-yloxy) cyclohexene-1-carboxylic acid, ester thereof and use thereof

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专利权人:

アレクサンドル・バシリエビッチ・イワシェンコ;アサヴィ・エルエルシー;アレクサンドル・バシリエビッチ・イワシェンコ

发明人:

アレクサンドル・バシリエビッチ・イワシェンコ

申请号：

JP2015512601

公开号：

JP6034960B2

申请日:

2013.05.07

申请国别(地区):

JP

年份:

2016

代理人:

摘要：

The present invention relates to novel neuraminidase activity inhibitors and use thereof for prophylaxis and treatment of influenza infection, that is, to fluorosubstituted 4-acetamido-5-guanidino-3-(pentan-3-yloxy)cyclohex-1-enecarboxylic acids, their esters of the general formula 1, pharmaceutically acceptable salts and/or hydrates thereof, wherein R represents hydrogen, optionally substituted C 1 -C 5 alkyl, C 2 -C 5 alkenyl or C 2 -C 5 alkynyl； Rf represents CH 2 F or CHF 2 . Pharmaceutical composition is given, method for its preparation, as well as method for prophylaxis and treatment of viral diseases.

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