Substituted fluorine (3r, 4r, 5s) -5-guanidino-4-acetamido-3- (pentan-3yloxy) cyclohexene-1-carboxylic acids, their esters and their use

• 收藏
• 分享

专利权人:

ASAVI, LLC;ALEXANDRE VASILIEVICH IVACHTCHENKO

发明人:

ALEXANDRE VASILIEVICH IVACHTCHENKO

申请号：

BR112014028362

公开号：

BR112014028362A2

申请日:

2013.05.07

申请国别(地区):

BR

年份:

2018

代理人:

摘要：

The present invention relates to novel neuraminidase activity inhibitors and use thereof for prophylaxis and treatment of influenza infection, that is, to fluorosubstituted 4-acetamido-5-guanidino-3-(pentan-3-yloxy)cyclohex-1-enecarboxylic acids, their esters of the general formula 1, pharmaceutically acceptable salts and/or hydrates thereof, wherein R represents hydrogen, optionally substituted C 1 -C 5 alkyl, C 2 -C 5 alkenyl or C 2 -C 5 alkynyl； Rf represents CH 2 F or CHF 2 . Pharmaceutical composition is given, method for its preparation, as well as method for prophylaxis and treatment of viral diseases.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/