2,3-DIDEOXY-5-FLUOROURIDINE DERIVATIVES, A PROCESS FOR THE MANUFACTURE THEREOF AND APPLICATION THEREOF

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专利权人:

发明人:

申请号：

EP14716996.5

公开号：

EP3105243B1

申请日:

2014.03.04

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

2&prime,3&prime-dideoxy-5-fluorouridine derivatives have general formula 1: wherein: R1 denotes cinchona alkaloid fragment with defined absolute configuration at C-8 and C-9 atoms. A process for the manufacture of 2&prime,3&prime-dideoxy-5-fluorouridine derivatives of general formula 1 and application of 2&prime,3&prime-dideoxy-5-fluorouridine derivatives of general formula 1 in the anticancer treatment of breast cancer, cervical cancer and hepatic cancer are also indicated.

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