2′, 3′-dideoxy-5-fluorouridine derivatives, a process for the manufacture thereof and application thereof

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专利权人:

发明人:

Lech Celewicz,Karol Kacprzak,Dagmara Baraniak,Marta Lewandowska,Piotr Ruszkowski

申请号：

US14413560

公开号：

US09388209B2

申请日:

2014.03.04

申请国别(地区):

US

年份:

2016

代理人:

摘要：

2′,3′-dideoxy-5-fluorouridine derivatives have general formula 1:wherein: R1 denotes cinchona alkaloid fragment with defined absolute configuration at C-8 and C-9 atoms. A process for the manufacture of 2′,3′-dideoxy-5-fluorouridine derivatives of general formula 1 and application of 2′,3′-dideoxy-5-fluorouridine derivatives of general formula 1 in the anticancer treatment of breast cancer, cervical cancer and hepatic cancer are also indicated.

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