Claim 1: A pyrazine derivative represented by formula (1) or one of its pharmaceutically acceptable salts, or one of its solvates, where X¹ represents a nitrogen or CH atom； R¹ represents a hydrogen atom, a C₁₋₆ alkyl group, a C₃₋₆ cycloalkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a halogen atom, a trifluoromethyl group, a difluoromethyl group, a group cyano, a C₂₋₇ alkylcarbonyl group, a C₁₋₆ alkylsulfonyl group, a nitro group, an amino group, a di (C₁₋₆ alkyl) amino group, a formyl group, a hydroxyl group, a C₁₋₆ alkoxy group, a C₁₋₆ alkylthio group,Or a group of phenyl or phenyl, which may be substituted by 1 to 3 r74919；Rᵃ represents a halogen atom, a C₁₋₆ alkyl group, a C₃₋₆ cycloalkyl group, or a C₁₋₆ alkoxy group； R² represents a C₁₋₆ alkyl group, a C₃₋₆ cycloalkyl group, or a C₁₋₆ alkoxy group； p represents any integer from 0 to 2； R³ represents a hydrogen atom, a C₁₋₆ alkyl group, a C₃₋₆ cycloalkyl group, a C₂₋₆ alkenyl group, a C₂₋₆ alkynyl group, a C₁₋₆ alkoxy group, a C₂₋₇ alkylcarbonyl group, a C₁₋₆alkylthio group, a halogen atom, a trifluoromethyl group, a difluoromethyl group, a cyano group, a phenyl group, a pyridyl group, a phenoxy group,Or coor74955；R83088 represents a tetrad-cour758080,-CONHSO - (C alquilo)Or any one of the formula groups (2)；Rᵇ and Rᶜ can be the same or different and represent a hydrogen atom, or a C₁₋₆ alkyl group； Z represents any of the groups represented by Z1 to Z7 of the group of formulas (3)；R⁵ represents a hydrogen atom or a C₁₋₆ alkyl group； R⁶ and R⁷ can be the same or different and represent a hydrogen atom, a halogen atom, a C₁₋₆ alkyl group, a C₁₋₆ alkoxy group, a trifluoromethyl group, a trifluoromethoxy group, a cyano group, a nitro group, or a phenoxy group, or R⁶ and R⁷ together form a C₁₋₃ alkylenedioxy group； R⁸,R8313,R830404,R1,R2,R3,R¹⁴ and R¹⁵ independently represent a hydrogen atom, a halogen atom, a C₁₋₆ alkyl group, a C₁₋₆ alkoxy group, a difluoromethyl group, a trifluoromethyl group, a cyano
