2′, 5′-dideoxy-5-fluorouridine derivatives having cytotoxic activity, a process for the manufacture thereof and application thereof

• 收藏
• 分享

专利权人:

发明人:

Lech Celewicz,Karol Kacprzak,Marta Lewandowska,Piotr Ruszkowski,Natalia Kleczewska

申请号：

US14413618

公开号：

US09605017B2

申请日:

2014.03.04

申请国别(地区):

US

年份:

2017

代理人:

摘要：

The subject matter of the invention is novel 2′,5′-dideoxy-5-fluorouridine derivatives of general formula 1.wherein R1 denotes cinchona alkaloid fragment with defined absolute configuration at C-8 and C-9 atoms.In a second aspect, the subject matter of the invention is a process for the manufacture of 2′,5′-dideoxy-5-fluorouridine derivatives of general formula 1.In a third aspect, the subject matter of the invention is an application of 2′,5′-dideoxy-5-fluorouridine derivatives of general formula 1 in the anticancer treatment of breast cancer, cervical cancer, lung cancer and nasopharynx cancer.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/