CHRISTOPH ULLMER,PETRA SCHMITZ,MARKUS RUDOLPH,PATRIZIO MATTEI,DANIEL HUNZIKER,JRME HERT
申请号：
ARP160102880
公开号：
AR106100A1
申请日:
2016.09.22
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
Compounds containing these compounds and their use in the treatment of eye diseases. 1. Requirement 1: formula compound (1),where: R¹ is substituted phenyl, (substituted phenyl) -C₁₋₆ alkyl,(phenyl substitution) - c83321c 83318326；(substituted phenyl) -C₂₋₆alkenyl,(substituted phenyl) -Cquin alkynyl,substituted pyridinyl, (substituted pyridinyl) -C₁₋₆-alkyl,(piridinilo replacement) - alquenilo c832283331；(substituted pyridinyl) -Cquin alkynyl,substituted thiophenyl, (substituted thiophenyl) -C₁₋₆-alkyl,(Tiofenilo sustituido) -alquenilo C o (tiofenilo sustituido) -alquinilo C(c) C832131-832626 tar was used to replace the phenyl；(phenyl substitution) - c83321c 83318326；(substituted phenyl) -C₂₋₆alkenyl,(substituted phenyl) -Cquin alkynyl,substituted pyridinyl, (substituted pyridinyl) -C₁₋₆-alkyl,(piridinilo replacement) - alquenilo c832283331；(substituted pyridinyl) -Cquin alkynyl,substituted thiophenyl, (substituted thiophenyl) -C₁₋₆-alkyl,(substituted thiophenyl) -C₂₋₆-alkenyl and (substituted thiophenyl) -Cquin-alkynyl are substituted by R³,R830808 and r83099；(b) One P-4, one P-3, one P-2, one P-3, one P-2,W is - C (o)-S (O) - o -CR R -R2. It is a phenyl substitute, pyridine substitute or sulfur fluorine substitute, phenyl substitute, pyridine substitute and sulfur fennilo substitute, changed to r8310；R831181 and r831222；R3: halogen, hydroxy, cyanogen, hydrocarbyl c83321c831832626；C₁₋₆ alkoxy,(alcoxi c83218c83316262) - rent for c83218c83316262,haloalkoxy C₁₋₆,haloalkyl C₁₋₆,hydroxy-C₁₋₆-alkyl,cycloalkyl C₃₋₈,(C₃₋₈ cycloalkyl) -C₁₋₆ alkyl,(C₃₋₈ cycloalkyl) -C₁₋₆ alkoxy,cycloalkoxy C₃₋₈,(cycloalcoxi c83223-83318328na) - asphalt c8321c833312626；Lease c8332121；(C₁₋₆-alkyl) -carbonylamino, (C₃₋₈-cycloalkyl) -carbonylamino, (C₁₋₆-alkyl) -tetrazolyl, (C₁₋₆-alkyl) -tetrazolyl-C₁₋₆-alkyl or C₁₋₆-heterocycloalkyl-alkoxy；R⁴ and R⁵ independently of one another are chosen from H, halogen, hydroxy, cyano, C₁₋₆ alkyl,C₁₋₆ alkoxy,(alcoxi c83218c83316262) - rent for c83218c83316262
