您的位置：
首页
>
农业专利
>
详情页
Double click compounds as dual inhibitors of ATX / Ca
- 专利权人:
- F. HOFFMANN-LA ROCHE AG
- 发明人:
- CHRISTOPH ULLMER,PETRA SCHMITZ,MARKUS RUDOLPH,PATRIZIO MATTEI,DANIEL HUNZIKER,JRME HERT,PATRICK DI GIORGIO
- 申请号：
- ARP160102879
- 公开号：
- AR106099A1
- 申请日:
- 2016.09.22
- 申请国别(地区):
- AR
- 年份:
- 2017
- 代理人:
- 摘要：
- 1. Requirement 1: formula compound (1),Wherein: R¹ is substituted phenyl, phenyl-C alqu-substituted alkyl, phenoxy-C₁₋₆-substituted alkyl, phenyl-C₂₋₆-substituted alkenyl, phenyl-C--substituted alkynyl, substituted quinolinyl, quinolinyl-C₁₋₆-alkyl substituted, substituted Colin quinolinyl-alkenyl, substituted C₂₋₆ quinolinyl-alkynyl, substituted pyridinyl, substituted C₁₋₆-pyridinyl-alkyl, substituted C pir-pyridinyl-alkenyl, substituted C₂₋₆-pyridinyl-substituted alkynyl, thiophenyl- C₁₋₆-substituted alkyl, C₂₋₆-substituted thiophenyl-alkenyl or C₂₋₆-substituted thiophenyl-alkynyl, said substituted phenyl,phenyl-C₁₋₆-substituted alkyl, phenoxy-C₁₋₆-substituted alkyl, phenyl-C₂₋₆-substituted alkenyl, phenyl-C₂₋₆-substituted alkynyl, substituted quinolinyl, quinolinyl-C₁₋₆-substituted alkyl, quinolinyl-C₂₋₆-substituted alkyl , substituted quinolinyl-C₂₋₆-alkynyl, substituted pyridinyl, pyridinyl-substituted C₁₋₆-alkyl, substituted pyridinyl-alkenyl-C,, substituted pyridinyl-C--alkynyl, substituted thiophenyl-substituted C ti-phenyl-alkenyl, thiophenyl-alkenyl C₂₋₆ substituted and thiophenyl-Cilo substituted alkynyl are substituted by R³,R830808 and r83099；This is a - OC (o) - O-C (o) -；W is - C (o)-S (O) - o -CR R -R2. It is a phenyl substitute, pyridine substitute or sulfur fluorine substitute, phenyl substitute, pyridine substitute and sulfur fennilo substitute, changed to r8310；R831181 and r831222；R3: halogen, hydroxy, cyanogen, hydrocarbyl c83321c831832626；C₁₋₆ alkoxy,(alcoxi c83218c83316262) - rent for c83218c83316262,haloalkoxy C₁₋₆,haloalkyl C₁₋₆,hydroxyalkyl C₁₋₆,cycloalkyl C₃₋₈,(C ciclo cycloalkyl) -C₁₋₆ alkyl,(cycloalkyl C₃₋₈) -alkoxy C₁₋₆,cycloalkoxy C₃₋₈,(cycloalcoxi c83223-83318328na) - asphalt c8321c833312626；Lease c8332121；(C₁₋₆-alkyl) -carbonylamino, (C₃₋₈-cycloalkyl) -carbonylamino, (C₁₋₆-alkyl) -tetrazolyl, (C₁₋₆-alkyl) -tetrazolyl-C₁₋₆-alkyl or C₁₋₆-heterocycloalkyl-alkoxy；R⁴ and R⁵ are independently chosen from H, halogen, hydroxy, cyano, C₁₋₆ al
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
