您的位置: 首页 > 农业专利 > 详情页

1h pyrazolo [4,3-b] pyridines as PDE1 inhibitors
专利权人:
H. LUNDBECK A/S
发明人:
申请号:
ARP170101836
公开号:
AR108941A1
申请日:
2017.07.03
申请国别(地区):
AR
年份:
2018
代理人:
摘要:
Claim 1: a compound according to formula (1) where l is selected from the group consisting ch₂, NH, s and o r¹ is selected from the group consisting of hydrogen,C₁₋₅ linear or branched alkyl, cycloalkyl c₃₋₅ monocyclic and fluoroalquilo c₁₋₅ saturated R² is selected from the group consisting of linear or branched alkyl c₁₋₈,Cycloalkyl c₃₋₈ monocyclic oxetanilo, saturatedTetrahidrofuranilo and tetrahidropiranilo all of which can be optionally replaced one or more times with one or more substituents selected from the group consisting of methylFluorine, Hydroxy, methoxy and methyl cyano r³ is substituted with phenyl piridonilo pyridinyl or pirazinilo pirimidinilo,,,All of which can be optionally replaced one or more times with one or more substituents selected from the group consisting c₁₋₃ Halogen, alkyl, cyano, fluoroalquilo c₁₋₃,Fluoroalcoxi c₁₋₃ and alkoxy c₁₋₃ or heteroaryl Methyl r³ is replaced with a 5 Member which is optionally substituted with one or more substituents selected from Halogen, cyano,C₁₋₃ fluoroalquilo c₁₋₃ alkyl, alkoxy, and fluoroalcoxi c₁₋₃ c₁₋₃ or r³ is Ethyl phenyl substituted pyridinyl piridonilo,,,Pirimidinilo pirazinilo or all of which may be optionally substituted by one or more times with one or more substituents selected from the group consisting of halogen, cyano,C₁₋₃ fluoroalquilo c₁₋₃ alkyl, alkoxy, and fluoroalcoxi c₁₋₃ c₁₋₃ r³ is Ethyl or heteroaryl substituted with a 5 MemberThat is optionally substituted with one or more substituents selected from Halogen, alkyl, cyano, c₁₋₃, fluoroalquilo c₁₋₃,Fluoroalcoxi c₁₋₃ and c₁₋₃ or alkoxy l is ch₂ and r³ is NH is substituted with phenyl piridonilo pyridinyl,,,Pirimidinilo pirazinilo or all of which may be optionally substituted by one or more times with one or more substituents selected from the group consisting of halogen, cyano,C₁₋₃ fluoroalquilo c₁₋₃ alkyl, alkoxy, and fluoroalcoxi c₁₋₃ c₁₋₃ or L is ch₂ and r³ is NH is replaced with a heteroaryl 5 members,That is optionally substitute
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充