The pyrazolpyridin derivatives described in this note generally interact with protein and self protein activities in Malta, in particular may hinder such activities. This paper also describes the synthesis of these pyridine derivatives and their use as drugs, especially through their interaction with Maltese and ancient protein activities. 1. Claim 1: a formula compound (1),or a pharmaceutically acceptable salt thereof, wherein: R¹ is halogen, cyano, or C₁₋₃ alkyl optionally substituted by halogen； R² is C₁₋₆ alkyl optionally substituted one or more times by C₁₋₆ alkyl,C₂₋₆ alkenyl,a. Hydroxy, N, n-dialquilo c833218331-832626-amine, n-mono-tar c83321c831832626-amine, o-r7501；R750101,phenyl, or by C₁₋₆ alkoxy,wherein the alkoxy may again be optionally substituted by C₁₋₆ alkoxy,N, N-dialkyl C₁₋₆-amino, Rᵍ or phenyl； C₃₋₆ cycloalkyl optionally substituted by C₁₋₆ alkyl,N N-dialquilo C -amino o alcoxilo C -alquilo CAnd / or two optional substitutes, together with the atoms to which they are attached, may form a saturated heterocyclic ring of 4 to 6 failed members or a helical ring of 1 to 2 oxygen atoms (or)；e. The alternative phenyl is alcoxilo c832131；a 5- to 6-membered heteroaryl ring having 1 to 3 heteroatoms selected from N and O, this ring being optionally substituted by C₁₋₆-alkyl which may be optionally substituted by amino, or hydroxyl； Rᵍ；or N, N-dialkyl C--aminocarbonyl； wherein: Rᵍ is a 5- to 6-membered heterocyclic ring having 1 to 3 heteroatoms selected from N and O, this ring being optionally substituted by C₁₋₆ alkyl,C₁₋₆-alkoxy-C₁₋₆-alkyl,2. Alcoxyl c833218d8331c26 carbides； R is the substitution of two or more times of phenyl with r749191 independently；2. R74955 was used to replace pyridine independently；3. R758080 was used to replace pyridine independently；O 4-independent pyrethrin, changed to r74966；where: Rᵃ independently of each other is halogen； cyano； -COO-C₁₋₆-alkyl；C₁₋₆ alkoxy；C₁₋₆-alkyl optionally substituted by halogen or a 5- to 6-membered
