DONOVAN NOEL CHIN,NATALIE DALES,ALEEM FAZAL,TIMOTHY BRIAN HURLEY,JOHN KERRIGAN,GARY OBRIEN,LEI SHU,MOO SUNG,ATWOOD KIM CHEUNG,ROBERT SUN
申请号：
ARP130102863
公开号：
AR092108A1
申请日:
2013.08.13
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Currently, active pharmaceutical preparations and combinations of pharmaceutical ingredients are provided. 1. Claim 1: compound or salt thereof calculated according to formula (1),A is 2-hydroxy-phenyl which is substituted by 0, 1, 2, or 3 substituents independently selected from C₁₋₄-alkyl,wherein 2 C₁₋₄ alkyl groups can combine with the atoms to which they are attached to form a 5-6 membered ring and is replaced by 0 or 1 substituents selected from oxo, oxime and hydroxyl, haloalkyl C₁₋₄,dihaloalkyl C₁₋₄,Trihaloalkyl c831832421；C₁₋₄ alkoxy,C₁₋₄-alkoxy-C₃₋₇ cycloalkyl,haloalkoxy C₁₋₄,dihaloalkoxy C₁₋₄,trihaloalkoxy C₁₋₄,hydroxyl, cyano, halogen, amino, mono- and di-C₁₋₄-amino, heteroaryl, C₁₋₄-alkyl substituted by hydroxyl, C₁₋₄-alkoxy substituted by aryl, amino, -C (O) NH-C₁₋₄-alkyl heteroaryl, -NHC (O) -heteroaryl-C₁₋₄-alkyl,C₁₋₄C₍O₎NH₋ₕₑₜₑʳₒₐʳⁱₗₒ alkyl,ₐₗqᵘⁱₗₒ C₁₋₄NHC (O) -heteroaryl, 3-7 membered cycloalkyl, 5-7 membered cycloalkenyl or 5-, 6- or 9-membered heterocycle containing 1 or 2 heteroatoms independently selected from S, O and N, in where heteroaryl has 5, 6 or 9 ring atoms, 1, 2 or 3 ring heteroatoms selected from N, O and S and substituted by 0, 1, or 2 substituents independently selected from oxo, hydroxyl, nitro, halogen, C₁₋₄-alkyl,C₁₋₄ alkenyl,C₁₋₄ alkoxy,cycloalkyl C₃₋₇,C₁₋₄-OH alkyl, C₁₋₄ trihaloalkyl,mono- y di-alquil C amino -C (O) NH-NH832222,-No.8322；hidroxi-alquil C amino hidroxialquilo C4-7 membered C₁₋₄ heterocycloalkyl, C₁₋₄ aminoalkyl and mono- and di-C₁₋₄-alkyl amino Cino alkyl；or A is 2-naphthyl optionally substituted at the 3-position by hydroxyl and additionally substituted by 0, 1, or 2 substituents selected from hydroxyl, cyano, halogen, C₁₋₄-alkyl,C₂₋₄ alkenyl,C₁₋₅ alkoxy,wherein the alkoxy is unsubstituted or substituted by hydroxyl, C₁₋₄ alkoxy,Amino, n (H) C (o) alkyl c831832421；N (H) C (O) ₂ alkyl C₁₋₄,4- to 7-membered alkylene heterocycle, 4- to 7-membered heterocycle and mono- and di-C₁₋₄amino alkyl； or A is 6-membered hete
