These include the pharmaceutical components of these compounds, the process for making them, and the use of these compounds in the treatment of diseases such as cancer. Claim 1: a compound of formula (1) or (2),including any of its tautomeric or stereochemically isomeric forms, wherein each R² is independently selected from hydroxyl, halogen, cyano, C₁₋₄ alkyl,C₂₋₄ alkenyl,1. C 83228331 asphalt；C₁₋₄ alkoxy,Calcium hydroxide c83216c831832424；Hydroxyl c83218c83183248a,C₁₋₄ haloalkyl,C₁₋₄ haloalkoxy,Hydroxyhalide c83217c83183248a,C₁₋₄ hydroxyhaloalkoxy,C₁₋₄ alkoxy-C₁₋₄ alkyl,C₁₋₄-C₁₋₄-alkyl haloalkoxy,C₁₋₄ alkoxy-C₁₋₄ alkyl,a. Each type of c83217c83183248axy can be optionally replaced by one or two hydroxyl subunits, hydroxyhaloxyc833183248axy acquilo c83216c833183248axy；R3,C83218331 replaced by R1 cube；C832138 replaced by - C (= O) - R1 cube；Alcox c83218c83318324 replaced by R1 3,Replace with - C (= O) - R1 3；-C (3DO) -Rc. C83231-8324 replaced by - NR 8311；； r831222；Replace c83218331 with - C (= O) - nr8311； r831222；a. Alcox c83218d318324 replaced by - nr8311；； r831222；Replaced by - C (= O) - nr8311；； r831222；-No. 8311； (r8322 y-c (= O) - No. 8311； (r831222)；O when two R2 groups are combined with adjacent carbon atoms, they can form a formula base together: O - (r1-831183) 832263； - O -；-X-CH=CH-；That's it, that's it.e. R831111 stands for hydrogen or fluorine, P stands for 1 or 2, x stands for O or s； and - cr1831222 = n-or18313 o-e-d； D stands for ring 3 to 12 single ring or double ring thyroid, or ring 3 to 12 single ring or double ring heterocycles, at least one of which is a heteromorphic atom selected from n, or 1. In O.S., one or more R1 groups (for example, 1, 2 or 3) can be selected to replace such carbohydrates and bicycles；E stands for link, - (square cube) 8345；,Alkein Cí-diyl optionally substituted with R²²,1. C83228331 - selectively substituted with r.2；-Co - (2 square cube) - 8347--(km2 3) - 8347； - Co,- second -2-3-(km2 3) - 8347； - NR2 --O - (km2) 8347
