БРАХМАНН Заскиа Мария (CH),ФИНАН Питер (US),ФРИЧ Кристине (FR),ГАРСИЯ-ЭЧЕВЕРРИЯ Карлос (CH),МЕРА Совёр-Мишель (FR),МЕРФИ Леон (US),НИКЛИН Пол Лесли (GB)
申请号：
RU2012110007/15
公开号：
RU2012110007A
申请日:
2012.03.15
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. The use of a compound of formula I in which R represents naphthyl or phenyl, wherein said phenyl is substituted with one or two substituents independently selected from the group consisting of halogen, lower alkyl, unsubstituted or substituted with halogen, cyano, imidazolyl or triazolyl, means cycloalkyl, amino substituted with one or two substituents independently selected from the group consisting of (lower) alkyl, (lower) alkylsulfonyl, (lower) alkoxy group and (lower) alkoxy (lower) alkylamino group means piperazinyl, unsubstituted or substituted with one or two substituents independently selected from the group consisting of (lower) alkyl and (lower) alkylsulfonyl, is 2-oxopyrrolidinyl, (lower) alkoxy (lower) alkyl, imidazolyl, pyrazolyl and triazolyl, R is O or S , R is lower alkyl, R is pyridyl unsubstituted or substituted with halogen, cyano, lower alkyl, lower alkoxy or piperazinyl unsubstituted or lower alkyl is pyrimidinyl, unsubstituted or substituted. ) alkoxy, means quinolinyl, unsubstituted or eschenny halogen denotes quinoxalinyl or phenyl substituted by alkoxy, is hydrogen or halogen, n is 0 or 1, Roboznachaet oxide. provided that if n is 1, then the N atom contained in the radical R is positively charged, R represents hydrogen or an amino group, or a tautomer thereof, or a pharmaceutically acceptable salt. or a hydrate or solvate thereof for the manufacture of a pharmaceutical preparation for the treatment of mTOR kinase-dependent diseases. 2. The use according to claim 1, where the compound of formula I is 2-methyl-2- [4- (3-methyl-2-oxo-8-�1. Применение соединения формулы I,в которомRобозначает нафтил или фенил, где указанный фенил замещен одним или двумя заместителями, независимо выбранными из группы, включающейгалоген,(низш.)алкил, незамещенный или замещенный галогеном, цианогруппой, имидазолилом или триазолилом,обозначает циклоалкил, аминогруппу, замещенную одним или двумя заместителями, независимо выбранными из группы, включающей (низш.)а
