Andrew Tasker;Hui-Ling Wang;Ryan Wurz;Liping H. Pettus;Bin Wu
发明人:
Liping H. Pettus,Andrew Tasker,Hui-Ling Wang,Bin Wu,Ryan Wurz
申请号：
US13060663
公开号：
US08455495B2
申请日:
2009.08.26
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula Iwherein A, R1, R2, R3, R4, R5, R6, X and n are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of p38 map kinase mediated diseases including rheumatoid arthritis, psoriasis, chronic obstructive pulmonary disease, pain and other inflammatory disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
